Fan Hua, Zheng Tong, Chen Yu, Yang Guang-Zhong
Department of Natural Products, College of Pharmacy, South Central University for Nationalities, Wuhan, P.R., China.
Pharmacogn Mag. 2012 Apr;8(30):98-102. doi: 10.4103/0973-1296.96549.
Fissistigma polyanthum is a liane belonging to the Annonaceae family and it is one of the most important crude drugs in traditional Chinese medicine.
The objective was to describe the structural elucidation and the free-radical-scavenging activities of the isolated compounds from Fissistigma polyanthum.
The chemical constituents were isolated and purified by normal, reverse column chromatography and HPLC. Their structures were identified by spectroscopic methods ((1)H NMR and (13)C NMR) and by comparison with literature values, and the free-radical-scavenging activities of these two compounds were also evaluated through three in vitro model systems (DPPH, trolox equivalent antioxidant capacity (TEAC) and Co (II) EDTA-induced luminol chemiluminescence by flow injection).
Two known compounds, named kanakugiol (1) and teutenone A (2), were isolated from the stem of Fissistigma polyanthum for the first time, and compound 1 exhibited moderate free-radical-scavenging activity.
Fissistigma polyanthum, which has traditionally been used as an important Chinese medicine, showed a certain free-radical-scavenging activity.
多花瓜馥木是番荔枝科的一种藤本植物，是传统中药中最重要的天然药物之一。
描述从多花瓜馥木中分离得到的化合物的结构解析及其自由基清除活性。
通过正相、反相柱色谱和高效液相色谱对化学成分进行分离和纯化。通过光谱方法（1H NMR和13C NMR）并与文献值比较鉴定其结构，还通过三种体外模型系统（DPPH、特洛克斯等效抗氧化能力（TEAC）和流动注射Co（II）乙二胺四乙酸诱导的鲁米诺化学发光）评估这两种化合物的自由基清除活性。
首次从多花瓜馥木茎中分离得到两种已知化合物，分别命名为卡那古醇（1）和特图烯酮A（2），化合物1表现出中等程度的自由基清除活性。
传统上用作重要中药的多花瓜馥木表现出一定的自由基清除活性。
