Sruogis Algimantas, Ulys Albertas, Smailyte Giedre, Kardelis Zygimantas, Kulboka Arunas, Anglickienė Giedre, Samalavicius Nerimantas, Anglickis Marius
Department of Urology, Institute of Oncology, Vilnius University, Santariški ų 1, 08660 Vilnius, Lithuania.
Prostate Cancer. 2012;2012:690210. doi: 10.1155/2012/690210. Epub 2012 Jun 3.
Objectives. To determine incidentally found prostate cancer frequency and impact on overall survival after RCP. Patients and Methods. The records of 81 men who underwent cystoprostatectomy from January 2000 to December 2009 were reviewed. The vital status of the study group was assessed as on September 1, 2009, by passive followup, using data from the population registry. Results. The 81 men underwent RCP. The incidental prostate cancer was found in the specimens of 27 (33.3%) patients. 13 (48.1%) of 27 prostate cancer cases were clinically significant. For 3 patients (11.1%) an extraprostatic extension was found. For 2 patients (7.4%)-positive margins, for 1 patient (3.7%)-Gleason sum 8, and for the rest 7 patients bigger than 0.5 cm(3) volume tumor, and Gleason sum 7 was found. The mean follow-up time was 39.2 ± 33.8 months (varies from 0.8 to 131.2 months). The patients with bladder cancer and incidentally found prostate cancer lived shorter (28.1 ± 27.5 and 45.5 ± 35.40 months). Higher overall survival (P = 0.03) was found in the patient group with bladder cancer without incidentally diagnosed prostate cancer. Conclusion. There are indications that in this small study prostate cancer has influenced on patients' survival with bladder cancer after radical cystoprostatectomy.
目的。确定根治性膀胱前列腺切除术后偶然发现的前列腺癌的发生率及其对总生存期的影响。
患者与方法。回顾了2000年1月至2009年12月期间接受膀胱前列腺切除术的81名男性的记录。采用人口登记数据,通过被动随访对研究组的生命状态进行评估,评估时间为2009年9月1日。
结果。81名男性接受了根治性膀胱前列腺切除术。27例(33.3%)患者的标本中发现了偶然前列腺癌。27例前列腺癌病例中有13例(48.1%)具有临床意义。3例(11.1%)发现有前列腺外侵犯。2例(7.4%)切缘阳性,1例(3.7%) Gleason评分8分,其余7例肿瘤体积大于0.5 cm³且Gleason评分7分。平均随访时间为39.2±33.个月(0.8至131.2个月不等)。患有膀胱癌且偶然发现前列腺癌的患者生存期较短(分别为28.1±27.5个月和45.5±35.40个月)。在未偶然诊断出前列腺癌的膀胱癌患者组中发现总生存期更高(P = 0.03)。
结论。有迹象表明,在这项小型研究中,前列腺癌对根治性膀胱前列腺切除术后膀胱癌患者的生存有影响。