在根治性膀胱前列腺切除术标本中偶然发现的前列腺腺癌的临床病理特征。
Clinicopathologic features of incidental prostatic adenocarcinoma in radical cystoprostatectomy specimens.
机构信息
Department of Surgical Pathology, Uludag University Medical Faculty, Bursa, Turkey.
出版信息
World J Surg Oncol. 2011 Jul 20;9:81. doi: 10.1186/1477-7819-9-81.
Abstract
BACKGROUND
The aim of this study is to review all features of incidentally discovered prostate adenocarcinoma in patients undergoing radical cystoprostatectomy for bladder cancer.
METHODS
The medical charts of 300 male patients who underwent radical cystoprostatectomy for bladder cancer between 1997 and 2005 were retrospectively reviewed. The mean age of the patients was 62 (range 51-75) years.
RESULTS
Prostate adenocarcinoma was present in 60 (20%) of 300 specimens. All were acinar adenocarcinoma. Of these, 40 (66.7%) were located in peripheral zone, 20 (33.3%) had pT2a tumor, 12 (20%) had pT2b tumor, 22(36.7%) had pT2c and, 6 (10%) had pT3a tumor. Gleason score was 6 or less in 48 (80%) patients. Surgical margins were negative in 54 (90%) patients, and tumor volume was less than 0.5 cc in 23 (38.3%) patients. Of the 60 incidentally detected cases of prostate adenocarcinoma 40 (66.7%) were considered clinically significant.
CONCLUSION
Incidentally detected prostate adenocarcinoma is frequently observed in radical cystoprostatectomy specimens. The majority are clinically significant.
摘要
背景
本研究旨在回顾因膀胱癌行根治性膀胱前列腺切除术时偶然发现的前列腺腺癌的所有特征。
方法
回顾性分析了 1997 年至 2005 年间 300 例行根治性膀胱前列腺切除术的男性患者的病历。患者平均年龄为 62 岁（51-75 岁）。
结果
300 例标本中发现前列腺腺癌 60 例（20%）。均为腺样腺癌。其中 40 例（66.7%）位于外周带，20 例（33.3%）为 T2a 肿瘤，12 例（20%）为 T2b 肿瘤，22 例（36.7%）为 T2c 肿瘤，6 例（10%）为 T3a 肿瘤。48 例（80%）患者的 Gleason 评分为 6 分或更低。54 例（90%）患者的手术切缘阴性，23 例（38.3%）患者的肿瘤体积小于 0.5cc。在 60 例偶然发现的前列腺腺癌中，40 例（66.7%）被认为具有临床意义。
结论
根治性膀胱前列腺切除术后标本中常偶然发现前列腺腺癌，且多数具有临床意义。
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