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Sorcin, a potential therapeutic target for reversing multidrug resistance in cancer.

作者信息

Zheng Bei-Bei, Zhang Peng, Jia Wei-Wei, Yu Lu-Gang, Guo Xiu-Li

机构信息

Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, People’s Republic of China.

出版信息

J Physiol Biochem. 2012 Jun;68(2):281-7. doi: 10.1007/s13105-011-0140-0.

DOI:10.1007/s13105-011-0140-0
PMID:22701893
Abstract
摘要

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Sorcin, a potential therapeutic target for reversing multidrug resistance in cancer.索辛蛋白，一种逆转癌症多药耐药性的潜在治疗靶点。
J Physiol Biochem. 2012 Jun;68(2):281-7. doi: 10.1007/s13105-011-0140-0.
2
Reversing effect of sorcin in the drug resistance of human nasopharyngeal carcinoma.sorcin 逆转人鼻咽癌耐药性的作用
Anat Rec (Hoboken). 2014 Feb;297(2):215-21. doi: 10.1002/ar.22832. Epub 2013 Dec 24.
3
Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells.阿霉素与索蛋白的结合会损害癌细胞的细胞死亡并增加耐药性。
Cell Death Dis. 2017 Jul 20;8(7):e2950. doi: 10.1038/cddis.2017.342.
4
The potential mechanism of action of Sorcin and its interacting proteins.索辛（Sorcin）及其相互作用蛋白的潜在作用机制。
Clin Chim Acta. 2020 Nov;510:741-745. doi: 10.1016/j.cca.2020.09.011. Epub 2020 Sep 15.
5
Reversing effect and mechanism of soluble resistance-related calcium-binding protein on multidrug resistance in human lung cancer A549/DDP cells.可溶性耐药相关钙结合蛋白对人肺癌A549/DDP细胞多药耐药的逆转作用及机制
Mol Med Rep. 2015 Mar;11(3):2118-24. doi: 10.3892/mmr.2014.2936. Epub 2014 Nov 13.
6
Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2.拉帕替尼（泰立沙，GW572016）通过抑制ATP结合盒亚家族B成员1和G成员2的活性来逆转癌细胞中的多药耐药性。
Cancer Res. 2008 Oct 1;68(19):7905-14. doi: 10.1158/0008-5472.CAN-08-0499.
7
Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells.索辛，一种参与癌细胞多药耐药机制的钙结合蛋白。
Molecules. 2014 Sep 5;19(9):13976-89. doi: 10.3390/molecules190913976.
8
Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca -mediated apoptosis pathways in MCF-7/ADR and K562/ADR.靶向 P-糖蛋白和 SORCIN：二氢杨梅素通过 MAPK/ERK 和 Ca 介导的凋亡通路增强阿霉素在 MCF-7/ADR 和 K562/ADR 中的抗增殖作用。
J Cell Physiol. 2018 Apr;233(4):3066-3079. doi: 10.1002/jcp.26087. Epub 2017 Nov 14.
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Sorcin induces a drug-resistant phenotype in human colorectal cancer by modulating Ca(2+) homeostasis.Sorcin 通过调节钙稳态诱导人结直肠癌细胞产生耐药表型。
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Soluble resistance-related calcium-binding protein in cancers.可溶性耐药相关钙结合蛋白在癌症中的研究进展。
Clin Chim Acta. 2018 Nov;486:369-373. doi: 10.1016/j.cca.2018.08.034. Epub 2018 Aug 23.

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Clinical Significance and Prognostic Value of Human Soluble Resistance-Related Calcium-Binding Protein: A Pan-Cancer Analysis.人可溶性抗性相关钙结合蛋白的临床意义及预后价值：一项泛癌分析
Front Med (Lausanne). 2021 Nov 16;8:752619. doi: 10.3389/fmed.2021.752619. eCollection 2021.
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Broad regulation of gene isoform expression by Wnt signaling in cancer.Wnt 信号在癌症中对基因异构体表达的广泛调控。
RNA. 2019 Dec;25(12):1696-1713. doi: 10.1261/rna.071506.119. Epub 2019 Sep 10.
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Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells.

本文引用的文献

1
Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp.sorcin 的过表达导致 P-gp 上调的胃癌细胞多药耐药。
Oncol Rep. 2011 Jan;25(1):237-43.
2
Mitochondrial chaperone Trap1 and the calcium binding protein Sorcin interact and protect cells against apoptosis induced by antiblastic agents.线粒体伴侣蛋白 Trap1 和钙结合蛋白 Sorcin 相互作用，保护细胞免受抗癌药物诱导的细胞凋亡。
Cancer Res. 2010 Aug 15;70(16):6577-86. doi: 10.1158/0008-5472.CAN-10-1256. Epub 2010 Jul 20.
3
Comparative proteomic profiling identified sorcin being associated with gemcitabine resistance in non-small cell lung cancer.
阿霉素与索蛋白的结合会损害癌细胞的细胞死亡并增加耐药性。
Cell Death Dis. 2017 Jul 20;8(7):e2950. doi: 10.1038/cddis.2017.342.
4
shRNA-mediated silencing of sorcin increases drug chemosensitivity in myeloma KM3/DDP and U266/ADM cell lines.短发夹RNA介导的索辛沉默增加了骨髓瘤KM3/DDP和U266/ADM细胞系的药物化学敏感性。
Int J Clin Exp Pathol. 2015 Mar 1;8(3):2300-10. eCollection 2015.
5
Resistance to paclitxel in breast carcinoma cells requires a quality control of mitochondrial antiapoptotic proteins by TRAP1.乳腺癌细胞对紫杉醇的耐药性需要 TRAP1 对线粒体抗凋亡蛋白进行质量控制。
Mol Oncol. 2013 Oct;7(5):895-906. doi: 10.1016/j.molonc.2013.04.009. Epub 2013 May 2.
比较蛋白质组学分析鉴定出 Sorcin 与非小细胞肺癌中吉西他滨耐药相关。
Med Oncol. 2010 Dec;27(4):1303-8. doi: 10.1007/s12032-009-9379-5. Epub 2009 Dec 10.
4
Gene expression profiling in sinonasal adenocarcinoma.鼻窦腺癌的基因表达谱分析。
BMC Med Genomics. 2009 Nov 10;2:65. doi: 10.1186/1755-8794-2-65.
5
Upregulation of soluble resistance-related calcium-binding protein (sorcin) in gastric cancer.胃癌中可溶性耐药相关钙结合蛋白（sorcin）的上调。
Med Oncol. 2010 Dec;27(4):1102-8. doi: 10.1007/s12032-009-9342-5. Epub 2009 Nov 3.
6
Is resistance useless? Multidrug resistance and collateral sensitivity.耐药性是否无用？多重耐药性与协同敏感性。
Trends Pharmacol Sci. 2009 Oct;30(10):546-56. doi: 10.1016/j.tips.2009.07.003. Epub 2009 Sep 15.
7
Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy.人乳腺癌中的膜联蛋白：新辅助化疗病理反应的潜在预测指标。
Eur J Cancer. 2009 May;45(7):1274-1281. doi: 10.1016/j.ejca.2008.12.026. Epub 2009 Jan 24.
8
Complex modulation of L-type Ca(2+) current inactivation by sorcin in isolated rabbit cardiomyocytes.索辛对离体兔心肌细胞L型钙电流失活的复杂调节作用。
Pflugers Arch. 2009 Mar;457(5):1049-60. doi: 10.1007/s00424-008-0575-5. Epub 2008 Sep 2.
9
Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha1C subunit in rabbits.索辛通过与兔心肌L型钙通道α1C亚基的功能性相互作用来调节L型钙电流。
Exp Physiol. 2008 Dec;93(12):1233-8. doi: 10.1113/expphysiol.2008.043497. Epub 2008 Jul 4.
10
[Influence of tetrandrine on SORCIN gene expression in K562/A02 cell line].汉防己甲素对K562/A02细胞系中SORCIN基因表达的影响
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Feb;16(1):65-9.