Deltz E, Schroeder P, Schweizer E, Gundlach M, Gebhardt H, Hansmann M L
Klinikum der Christian-Albrecht-Universität zu Kiel.
Schweiz Rundsch Med Prax. 1990 Dec 18;79(51):1586-8.
The problems of surgical technique, graft physiology and immunological reactions in small-bowel transplantation have been investigated in extended animal experiments. In these experiments, the fundamentals of a successful clinical application of small-bowel transplantation could be laid. A successful human small-bowel transplantation could be carried out by the Kiel Group for the first time in 1988. A graft which had been removed from a related donor showed a complete adaptation after 22 months, so that the patient became completely independent from parenteral nutrition. After that, in several cases small-bowel and combined liver and small-bowel transplantation have been carried out. Thus, the clinical small-bowel transplantation represents the causal therapy of short-bowel syndrome and should be developed in further clinical trials.
在大量动物实验中研究了小肠移植中的外科技术、移植物生理学和免疫反应问题。在这些实验中，可以奠定小肠移植成功临床应用的基础。1988年，基尔研究小组首次成功进行了人体小肠移植。从相关供体获取的移植物在22个月后显示出完全适应，患者完全不再依赖肠外营养。此后，又进行了几例小肠移植以及肝小肠联合移植。因此，临床小肠移植是短肠综合征的病因治疗方法，应在进一步的临床试验中加以发展。
