Conen D, Humbel S
Departement Innere Medizin, Kantonsspital Basel.
Schweiz Med Wochenschr. 1990 Dec 15;120(50):1945-9.
Prescribing patterns of 13 residents in a medical outpatient clinic were evaluated between March and June 1986. Prescribed drugs influencing the gastrointestinal tract were also analyzed in order to define quality of the therapeutic process. Advertising for these special drugs in 3 Swiss medical journals was analyzed and compared with the prescribing behavior of participating physicians. 6300 patients with 3346 prescriptions (0.5 prescription/patient) were enrolled in the study. 16.5% of all prescriptions involved cardiovascular, 13.5% gastrointestinal, 9.5% non steroidal antirheumatic, 9.1% analgesic, 7.7% psychotropic and 7.4% antibiotic drugs. The share of 14 other classes of drugs was less than 4%. 471 prescriptions of gastrointestinal acting drugs were distributed over 288 patients (0.6 prescription/patient). 160 patients had irritable bowel syndrome, 40 ulcer disease, 23 inflammatory/infectious bowel disease, 18 gastroesophageal reflux, 18 anal diseases, 11 other gastrointestinal disorders and 15 were treated without diagnosis. Distribution of drugs was as follows: 27.5% bulk laxatives, 26% antacids, 15.7% H2-receptor antagonists, 13.5% anticholinergic agents, 4.9% laxatives, 3.4% loperamide, 9% other drugs. There was an increase in prescriptions per visit from 0.8 in 1980 to 1.5 in 1986. No important influence of drug advertising in 3 different medical journals published between January and June 1986 could be found. Considering the documented diagnoses, the therapeutic decisions were correct in 95.5% of cases treated. In conclusion, drug prescribing habits are permissive, the therapeutic approach is acceptable and the influence of drug advertising is negligible.
1986年3月至6月期间,对一家门诊诊所的13名住院医师的处方模式进行了评估。还对影响胃肠道的处方药进行了分析,以界定治疗过程的质量。分析了3种瑞士医学期刊上这些特殊药物的广告,并与参与研究的医生的处方行为进行了比较。该研究共纳入6300名患者,开出3346张处方(平均每位患者0.5张处方)。所有处方中,16.5%涉及心血管药物,13.5%涉及胃肠道药物,9.5%涉及非甾体类抗风湿药物,9.1%涉及止痛药物,7.7%涉及精神药物,7.4%涉及抗生素药物。其他14类药物的占比均不到4%。471张胃肠道作用药物处方分布在288名患者中(平均每位患者0.6张处方)。160名患者患有肠易激综合征,40名患有溃疡病,23名患有炎症性/感染性肠病,18名患有胃食管反流病,18名患有肛门疾病,11名患有其他胃肠道疾病,15名患者在未明确诊断的情况下接受了治疗。药物分布如下:27.5%为容积性泻药,26%为抗酸剂,15.7%为H2受体拮抗剂,13.5%为抗胆碱能药物,4.9%为缓泻剂,3.4%为洛哌丁胺,9%为其他药物。每次就诊的处方量从1980年的0.8张增加到了1986年的1.5张。未发现1986年1月至6月期间出版的3种不同医学期刊上的药物广告有重要影响。考虑到已记录的诊断,95.5%的治疗病例中的治疗决策是正确的。总之,药物处方习惯较为随意,治疗方法可以接受,药物广告的影响可以忽略不计。