Department of Pediatric SCT, Leiden University Medical Centre, Leiden, The Netherlands.
Bone Marrow Transplant. 2013 Jan;48(1):40-5. doi: 10.1038/bmt.2012.102. Epub 2012 Jun 18.
Since 1968, when Leiden undertook the first successful European pediatric BM transplantation with a 7-year-old sibling donor, more than 300 young children have donated BM in our unit. We first retrospectively studied a cohort of 210 donors, younger than 13 years at donation, to survey procedures of donor eligibility and study immediate effects of BM donation. We then performed a long-term follow-up (FU) and health-related quality of life (HRQoL) study. Despite documentation of previous medical conditions, no child was declared unfit to donate. We found that iron deficiency anemia or low-iron stores in BM did not result in treatment or extended FU. Harvest volumes exceeded 15 mL/kg in 65% of donors, with more than half requiring allogeneic blood transfusions. Donors had no structured FU after their first post-donation control. In this study, 25% of donors reported at least one somatic complaint at long-term FU. Finally long-term HRQoL revealed high scores in most subdomains (representing a higher QoL), compared to norm groups. These results indicate the need for development of (inter)national guidelines for pediatric stem cell donor care management.
自 1968 年莱顿（荷兰城市）首次使用 7 岁的同胞供者进行成功的儿科骨髓移植以来，已有 300 多名幼儿在我们的单位捐献了骨髓。我们首先回顾性研究了一组 210 名捐赠者，他们在捐赠时年龄小于 13 岁，以调查捐赠者资格的程序，并研究骨髓捐献的即时影响。然后，我们进行了长期随访（FU）和健康相关生活质量（HRQoL）研究。尽管有先前疾病的记录，但没有孩子被宣布不适合捐献。我们发现，铁缺乏性贫血或骨髓中的低铁储量不会导致治疗或延长 FU。65%的供者采集量超过 15ml/kg，超过一半需要异体输血。供者在第一次捐献后控制后没有进行结构化 FU。在这项研究中，25%的供者在长期 FU 时报告至少有一个躯体抱怨。最后，长期 HRQoL 显示大多数子领域（代表更高的生活质量）的得分较高，与对照群体相比。这些结果表明需要制定（国际）儿科干细胞供者护理管理指南。
