Zimecki Michał
Department of Experimental Therapy, The Institute of Immunology and Experimental Therapy, Wrocław, Poland. mail:
Postepy Hig Med Dosw (Online). 2012 May 30;66:287-94. doi: 10.5604/17322693.998859.
Prevention and treatment of pathological inflammatory processes requires application of various classes of immune suppressors, such as calcineurin inhibitors, steroids and non-steroid inhibitors of prostaglandin synthesis. However, each type of these immune suppressors causes less or more serious adverse side-effects. Exploration of the role played by prostanoids in the immune response and identification of functionally distinct prostaglandin E receptors (EP1-EP4) opened new perspectives in therapy of inflammation, autoimmunity and prevention of graft rejection. The EP4 receptor appeared to be an attractive target to affect manifestations of various pathological states by application of either agonists or antagonists of the receptor. This article presents a short overview of experimental approaches aimed at manipulation of signaling via EP2 and EP4 receptors that could have therapeutic utility.
病理性炎症过程的预防和治疗需要应用各类免疫抑制剂，如钙调神经磷酸酶抑制剂、类固醇以及前列腺素合成的非类固醇抑制剂。然而，这些免疫抑制剂中的每一种都会或多或少地引发严重的不良副作用。对前列腺素类在免疫反应中所起作用的探索以及对功能各异的前列腺素E受体（EP1 - EP4）的鉴定，为炎症、自身免疫性疾病的治疗以及移植排斥反应的预防开辟了新的前景。EP4受体似乎是一个有吸引力的靶点，通过应用该受体的激动剂或拮抗剂来影响各种病理状态的表现。本文简要概述了旨在通过EP2和EP4受体操纵信号传导的实验方法，这些方法可能具有治疗用途。
