宫颈人乳头瘤病毒感染与宫颈阴道液中人类免疫缺陷病毒的脱落：一项横断面研究。

Cervical human papillomavirus infection and shedding of human immunodeficiency virus in cervicovaginal fluids: a cross-sectional study.

机构信息

Institute of Infectious and Tropical Diseases, Spedali Civili Hospital and University of Brescia, Brescia, Italy.

出版信息

J Acquir Immune Defic Syndr. 2012 Sep 1;61(1):78-82. doi: 10.1097/QAI.0b013e31826327a0.

Abstract

We evaluated the association between human papillomavirus cervical infection and HIV shedding in cervicovaginal lavage fluid (CVL), studying 89 HIV-infected women recruited at the Department of Infectious Diseases of Brescia (Italy). HIV shedding in CVL was found in a similar proportion of women with (30%; 21/70) and without (31.6%; 6/19) cervical human papillomavirus infection. A statistically significant correlation was found between HIV viral load in serum and CVL among the 27 women with detectable HIV in CVL (r = 0.4; P = 0.04). However, women on highly active antiretroviral therapy were more likely to have detectable HIV-RNA in CVL despite negative viremia (80% vs. 8%; P < 0.005).

摘要

我们评估了人乳头瘤病毒（HPV）宫颈感染与 HIV 在宫颈阴道灌洗液（CVL）中脱落之间的关系，共招募了 89 名在布雷西亚传染病科（意大利）就诊的 HIV 感染者。在 HPV 阳性（30%，21/70）和 HPV 阴性（31.6%，6/19）的女性中，CVL 中 HIV 脱落的比例相似。在 27 名 CVL 中可检测到 HIV 的女性中，血清中 HIV 载量与 CVL 之间存在统计学显著相关性（r = 0.4；P = 0.04）。然而，尽管病毒血症阴性，接受高效抗逆转录病毒治疗的女性更有可能在 CVL 中检测到 HIV-RNA（80%比 8%；P < 0.005）。