Brandt S, Lohe B, Vogetseder A, Rüdiger T, Moch H, Bode P
Institut für Klinische Pathologie, Universitätsspital Zürich, Schmelzbergstr. 12, 8091, Zürich, Schweiz.
Pathologe. 2013 Feb;34(1):70-3. doi: 10.1007/s00292-012-1608-6.
We describe a case of a testicular primitive neuroectodermal tumor (PNET) with intratubular germ cell neoplasia of the adjacent testicular parenchyma. The occurrence of testicular PNET is rare because malignant transformation of testicular germ cell tumors into somatic malignancy is uncommon. Based on morphological, immunohistochemical and molecular pathological findings these tumors resemble central PNETs as they otherwise typically occur in children without rearrangement of the Ewing sarcoma breakpoint region (EWSR) gene on chromosome 22. This case also showed no evidence for a translocation.
我们描述了一例睾丸原始神经外胚层肿瘤（PNET），其相邻睾丸实质存在小管内生殖细胞肿瘤。睾丸PNET的发生较为罕见，因为睾丸生殖细胞肿瘤向体细胞恶性肿瘤的恶性转化并不常见。基于形态学、免疫组织化学和分子病理学结果，这些肿瘤类似于中枢性PNET，因为它们通常发生在儿童中，且22号染色体上的尤因肉瘤断点区域（EWSR）基因无重排。该病例也未显示有易位的证据。
