Fu Cuiping, Peng Yu, Liao Xinli, Guo Chenyun, Lin Donghai
The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Biomol NMR Assign. 2013 Oct;7(2):155-8. doi: 10.1007/s12104-012-9399-5. Epub 2012 Jun 17.
AK1 (Adenylate Kinase 1) plays crucial roles in processes such as cellular phosphotransfer networks, neuronal maturation and regeneration, gating of ABC transporter CFTR, tumor cell metabolism and myocardial energetic homeostasis. Here we report (1)H, (15)N and (13)C backbone and side-chain resonance assignments of the human AK1 protein in apo form. This work lays the essential basis for the further structure determination of hAK1.
腺苷酸激酶1（AK1）在细胞磷酸转移网络、神经元成熟与再生、ABC转运蛋白CFTR的门控、肿瘤细胞代谢以及心肌能量稳态等过程中发挥着关键作用。在此，我们报道了人源apo形式AK1蛋白的（1）H、（15）N和（13）C主链及侧链共振归属。这项工作为进一步确定hAK1的结构奠定了重要基础。
