氯丙嗪（CPZ）对免疫系统发育成熟和未发育成熟小鼠的淋巴细胞脉络丛脑膜炎病毒感染病程的影响。
Effect of chlorpromazine (CPZ) on the course of LCM virus infection in mice with developed and undeveloped immune system.
作者信息
Szeri I, Anderlik P, Bános Z, Csatáry L K, Nász I, Barna Z
机构信息
Institute of Microbiology, Semmelweis University Medical School, Budapest, Hungary.
出版信息
Acta Microbiol Hung. 1990;37(2):171-8.
The cellular immune response to lymphocytic choriomeningitis (LCM) virus in germfree adult and conventional (Cv) suckling mice with undeveloped immune systems and in Cv adult mice with developed immune systems was suppressed by a single large, sublethal dose of the calmodulin antagonistic chlorpromazine and stimulated by a 100-times smaller dose administered intraperitoneally one day before the intracerebral virus infection. CPZ thus exerted a two-directional dose-dependent immunomodulatory effect in mice with both undeveloped and developed immune system.
在无菌成年小鼠和免疫系统未发育的常规（Cv）乳鼠以及免疫系统已发育的Cv成年小鼠中，针对淋巴细胞性脉络丛脑膜炎（LCM）病毒的细胞免疫反应，会被单次大剂量、亚致死量的钙调蛋白拮抗剂氯丙嗪所抑制，而在脑内病毒感染前一天腹腔注射小100倍的剂量则会刺激该反应。因此，氯丙嗪在免疫系统未发育和已发育的小鼠中均发挥了双向剂量依赖性免疫调节作用。
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