Ali S, Addley J, Johnston S, Carey D, McManus D
Department of Gastroenterology, Whiteabbey Hospital, Belfast, UK.
BMJ Case Rep. 2011 Feb 17;2011:bcr0120102674. doi: 10.1136/bcr.01.2010.2674.
Gastrointestinal stromal tumours (GISTs) are a subset of gastrointestinal (GI) mesenchymal tumours of varying differentiation and represent 1-3% of all gastrointestinal malignancies--70% occur in the stomach. Previously, these tumours were classified as GI leiomyomas, leiomyosarcomas, leiomyoblastomas or schwannomas on the basis of histological findings and the fact that these tumours apparently originate in the muscularis propria layer of the intestinal wall. With the advent of immunohistochemical staining techniques and ultrastructural evaluation, GISTs are now recognised as a distinct group of mesenchymal tumours. Most cases are sporadic although some families with hereditary GISTs have been described. We report a coinicidental finding of GIST in an asymptomatic patient and subsequent management.
胃肠道间质瘤(GISTs)是胃肠道(GI)间充质肿瘤的一个子集,具有不同程度的分化,占所有胃肠道恶性肿瘤的1% - 3%,其中70%发生在胃。以前,这些肿瘤根据组织学发现以及它们显然起源于肠壁固有肌层这一事实,被分类为胃肠道平滑肌瘤、平滑肌肉瘤、成平滑肌细胞瘤或神经鞘瘤。随着免疫组织化学染色技术和超微结构评估的出现,GISTs现在被认为是一组独特的间充质肿瘤。大多数病例是散发性的,尽管已经描述了一些患有遗传性GISTs的家族。我们报告了一名无症状患者偶然发现GIST以及后续治疗情况。