Department of Psychiatry, Firat University, School of Medicine, Elazig, Turkey.
Psychiatry Investig. 2012 Jun;9(2):161-5. doi: 10.4306/pi.2012.9.2.161. Epub 2012 Apr 30.
In the present study, we measured hippocampal N-acetyl-l-aspartate (NAA), choline (CHO) and creatine (CRE) values in patients with panic disorder and healthy control subjects using in vivo(1)H MRS.
We scanned 20 patients meeting Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) criteria for panic disorder and 20 matched healthy controls with a 1.5 Tesla GE Signa Imaging System and measured of NAA, CHO, and CRE in hippocampal regions.
When NAA, CHO and CRE values were compared between groups, statistically significant lower levels for all ones were detected for both sides.
Consequently, in the present study we found that NAA, CHO and CRE values of the patients with panic disorder were lower than those healthy controls. Future studies involving a large number of panic patients may shed further light on the generalizability of the current findings to persons with panic disorder.
在本研究中，我们使用体内（1）H MRS 测量了惊恐障碍患者和健康对照者的海马 N-乙酰-l-天冬氨酸（NAA）、胆碱（CHO）和肌酸（CRE）值。
我们使用 1.5 Tesla GE Signa 成像系统对符合精神障碍诊断与统计手册第四版（DSM-IV）标准的 20 例惊恐障碍患者和 20 例匹配的健康对照者进行了扫描，并测量了海马区域的 NAA、CHO 和 CRE。
当比较组间 NAA、CHO 和 CRE 值时，两侧均检测到所有值均显著降低。
因此，在本研究中，我们发现惊恐障碍患者的 NAA、CHO 和 CRE 值低于健康对照组。未来涉及大量惊恐障碍患者的研究可能会进一步阐明当前发现对惊恐障碍患者的普遍性。
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