Schunck Thérèse, Erb Gilles, Mathis Alexandre, Gilles Christian, Namer Izzie Jacques, Hode Yann, Demaziere Agnès, Luthringer Rémy, Macher Jean-Paul
Forenap-Unité RMN, 27, rue du 4ème RSM, 68250 Rouffach, France.
Neuroimage. 2006 Jul 1;31(3):1197-208. doi: 10.1016/j.neuroimage.2006.01.035. Epub 2006 Apr 5.
The main objective of this work was to study the functional markers of the clinical response to cholecystokinin tetrapeptide (CCK-4). Twelve healthy male subjects were challenged with CCK-4 and simultaneously underwent functional magnetic resonance imaging (fMRI) recording. Since anticipatory anxiety (AA) is an intrinsic part of panic disorder, a behavioral paradigm, using the threat of being administered a second injection of CCK-4, has been developed to investigate induced AA. The study was composed of three fMRI scans according to an open design. During first and second scan, subjects were injected with placebo and CCK-4, respectively. The third scan was the AA challenge. CCK-4 administration induced physiological and psychological symptoms of anxiety that met the criteria for a panic attack in 8 subjects, as well as cerebral activation in anxiety-related brain regions. Clinical and physiological response intensity was consistent with cerebral activity extent and robustness. fMRI proved more sensitive than clinical assessment in evidencing the effects of the AA challenge. The latter induced brain activation, different from that obtained on CCK-4 and during placebo injection, that was likely related to anxiety. The method applied in this study is suitable for the study of anxiety using fMRI.
这项工作的主要目的是研究对胆囊收缩素四肽（CCK - 4）临床反应的功能标志物。12名健康男性受试者接受CCK - 4激发，并同时进行功能磁共振成像（fMRI）记录。由于预期焦虑（AA）是惊恐障碍的一个内在组成部分，已开发出一种行为范式，利用第二次注射CCK - 4的威胁来研究诱发的AA。该研究根据开放设计由三次fMRI扫描组成。在第一次和第二次扫描期间，受试者分别注射安慰剂和CCK - 4。第三次扫描是AA激发。注射CCK - 4诱发了焦虑的生理和心理症状，8名受试者出现了符合惊恐发作标准的症状，以及焦虑相关脑区的大脑激活。临床和生理反应强度与大脑活动程度和强度一致。在证明AA激发的效果方面，fMRI比临床评估更敏感。后者诱发的大脑激活不同于CCK - 4注射时和安慰剂注射期间获得的激活，这可能与焦虑有关。本研究中应用的方法适用于使用fMRI进行焦虑研究。
