Narita Minoru, Ikegami Daigo, Yamashita Akira, Ushijima Toshikazu
Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Nihon Shinkei Seishin Yakurigaku Zasshi. 2012 Apr;32(2):63-72.
Clinically, it is well-known that chronic pain induces depression, anxiety, and reduced quality of life. Neuropathic pain, which is characterized by spontaneous burning pain, hyperalgesia and allodynia, is the most difficult pain to manage in the pain clinic. However, the complicated pathophysiology of neuropathic pain is not yet understood. A better understanding of its pathophysiology has given us more insight into its various mechanisms and possible treatment options. This review will explore the most current issues in the field of pain, with a focus on transcriptional research, epigenetic research and post-transcriptional research. For a global understanding of the pain, it is necessary to analyze the correlation between these temporal parameters and phenomics.
临床上，众所周知，慢性疼痛会引发抑郁、焦虑并降低生活质量。神经性疼痛以自发性灼痛、痛觉过敏和感觉异常为特征，是疼痛门诊最难处理的疼痛类型。然而，神经性疼痛复杂的病理生理学仍未被理解。对其病理生理学的更好理解使我们对其各种机制和可能的治疗选择有了更深入的了解。本综述将探讨疼痛领域的最新问题，重点关注转录研究、表观遗传学研究和转录后研究。为了全面了解疼痛，有必要分析这些时间参数与表型组学之间的相关性。
