Department of Intensive Care and Intermediate Care, University Hospital Aachen, RWTH Aachen University, Aachen, Germany.
Curr Protein Pept Sci. 2012 Jun;13(4):391-400. doi: 10.2174/138920312801619484.
Studies on the post-transcriptional control of gene expression in hematopoietic cells have uncovered that a subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs) is involved in cytoplasmic gene regulation. Among them hnRNP K and hnRNPs E1/E2 share common structural motifs, the hnRNP K homology (KH) domains that provide a functional basis for RNA binding. Specific sub-cellular localization and differentiation dependent post-translational modifications modulate the interaction of these proteins with mRNA and proteins in messenger ribonucleoprotein complexes (mRNPs), the latter generating connectivity to cell signaling events. As components of different mRNPs, hnRNP K and hnRNPs E1/E2 function as crucial modulators of mRNA stability and translation in hematopoietic cell differentiation.
在造血细胞中转录后基因表达的调控研究中发现，一类异质核核糖核蛋白（hnRNP）参与了细胞质基因调控。其中 hnRNP K 和 hnRNP E1/E2 具有共同的结构基序，hnRNP K 同源（KH）结构域为 RNA 结合提供了功能基础。特定的亚细胞定位和分化依赖的翻译后修饰调节这些蛋白与信使核糖核蛋白复合物（mRNPs）中的 mRNA 和蛋白质的相互作用，后者与细胞信号事件产生连接。作为不同 mRNPs 的组成部分，hnRNP K 和 hnRNP E1/E2 在造血细胞分化中作为 mRNA 稳定性和翻译的关键调节剂发挥作用。
