Usuki S
Department of Obstetrics and Gynecology, University of Tsukuba, Ibaraki, Japan.
Am J Chin Med. 1990;18(3-4):149-56. doi: 10.1142/S0192415X90000198.
The effect of Tokishakuyakusan (TS) and Keishibukuryogan (KB) on estradiol-17 beta, progesterone and testosterone in serum and ovarian tissue from PMS-treated immature rats was examined in vivo. The in vivo intravenous administration of 20 micrograms of TS or KB increased the concentrations of estradiol-17 beta, progesterone and testosterone. These results suggest that TS and KB stimulate in vivo the production of estradiol-17 beta, progesterone and testosterone by preovulatory follicles, and that TS stimulation is more effective than KB.