通过形式反转不对称合成 α-手性 γ-酮酯。
Enantioselective synthesis of α-stereogenic γ-keto esters via formal umpolung.
机构信息
Loker Hydrocarbon Research Institute, Department of Chemistry, University of Southern California, Los Angeles, California 90089-1661, USA.
出版信息
Org Lett. 2012 Jul 6;14(13):3260-3. doi: 10.1021/ol301112m. Epub 2012 Jun 18.
PMID:22708653
Abstract
A feasible method has been developed for the enantioselective synthesis of α-stereogenic γ-keto esters. By employing nitro(phenylsulfonyl)methane as an acyl anion equivalent, the integrated Michael addition reaction-oxidative methanolysis protocol allows the preparation of various γ-keto esters with high optical purities.
摘要
已开发出一种可行的方法，用于对映选择性合成α-立体手性γ-酮酯。通过使用硝基（苯磺酰基）甲烷作为酰基阴离子等价物，集成的迈克尔加成反应-氧化甲醇解方案允许用高光学纯度制备各种γ-酮酯。
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