• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

危重症患者的他汀类药物治疗。

Statins in the critically ill.

机构信息

Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B-1070, Brussels, Belgium.

出版信息

Ann Intensive Care. 2012 Jun 18;2(1):19. doi: 10.1186/2110-5820-2-19.

DOI:10.1186/2110-5820-2-19
PMID:22709377
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3488539/
Abstract

The use or misuse of statins in critically ill patients recently attracted the attention of intensive care clinicians. Indeed, statins are probably the most common chronic treatment before critical illness and some recent experimental and clinical data demonstrated their beneficial effects during sepsis, acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), or after aneurismal subarachnoidal hemorrhage (aSAH). Due to the heterogeneity of current studies and the lack of well-designed prospective studies, definitive conclusions for systematic and large-scale utilization in intensive care units cannot be drawn from the published evidence. Furthermore, the extent of statins side effects in critically ill patients is still unknown. For the intensive care clinician, it is a matter of individually identifying the patient who can benefit from this therapy according to the current literature. The purpose of this review is to describe the mechanisms of actions of statins and to synthesize the clinical data that underline the relevant effects of statins in the particular setting of critical care, in an attempt to guide the clinician through his daily practice.

摘要

他汀类药物在危重症患者中的使用或误用最近引起了重症监护临床医生的关注。事实上,他汀类药物可能是危重病前最常见的慢性治疗药物,一些最近的实验和临床数据表明它们在脓毒症、急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)或蛛网膜下腔出血(aSAH)后具有有益作用。由于当前研究的异质性和缺乏精心设计的前瞻性研究,目前还不能从已发表的证据中得出关于在重症监护病房系统和大规模使用他汀类药物的明确结论。此外,他汀类药物在危重症患者中的副作用程度仍不清楚。对于重症监护临床医生来说,根据当前的文献,根据个体患者的情况来确定他们是否能从这种治疗中获益是一个问题。本综述的目的是描述他汀类药物的作用机制,并综合临床数据,阐明他汀类药物在重症监护特定环境中的相关作用,试图指导临床医生进行日常实践。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39b/3488539/a0ea0d1a58b6/2110-5820-2-19-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39b/3488539/5d8a42740d68/2110-5820-2-19-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39b/3488539/a0ea0d1a58b6/2110-5820-2-19-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39b/3488539/5d8a42740d68/2110-5820-2-19-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39b/3488539/a0ea0d1a58b6/2110-5820-2-19-2.jpg

相似文献

1
Statins in the critically ill.危重症患者的他汀类药物治疗。
Ann Intensive Care. 2012 Jun 18;2(1):19. doi: 10.1186/2110-5820-2-19.
2
Statins for the prevention and treatment of acute lung injury and acute respiratory distress syndrome: A systematic review and meta-analysis.他汀类药物用于预防和治疗急性肺损伤及急性呼吸窘迫综合征:一项系统评价和荟萃分析。
Respirology. 2016 Aug;21(6):1026-33. doi: 10.1111/resp.12820. Epub 2016 May 24.
3
Feeding the critically ill obese patient: a systematic review protocol.为危重症肥胖患者提供营养支持:一项系统评价方案
JBI Database System Rev Implement Rep. 2015 Oct;13(10):95-109. doi: 10.11124/jbisrir-2015-2458.
4
The effectiveness of interventions to meet family needs of critically ill patients in an adult intensive care unit: a systematic review update.成人重症监护病房中满足重症患者家庭需求的干预措施的有效性:系统评价更新
JBI Database System Rev Implement Rep. 2016 Mar;14(3):181-234. doi: 10.11124/JBISRIR-2016-2477.
5
Extracorporeal lung support technologies - bridge to recovery and bridge to lung transplantation in adult patients: an evidence-based analysis.体外肺支持技术——成人患者的康复桥梁和肺移植桥梁:一项基于证据的分析
Ont Health Technol Assess Ser. 2010;10(5):1-47. Epub 2010 Apr 1.
6
To Block or Not: Updates in Neuromuscular Blockade in Acute Respiratory Distress Syndrome.是否阻断:急性呼吸窘迫综合征中神经肌肉阻滞的新进展。
Ann Pharmacother. 2020 Sep;54(9):899-906. doi: 10.1177/1060028020910132. Epub 2020 Feb 28.
7
Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome.重症急性呼吸综合征危重症患者的急性呼吸窘迫综合征
JAMA. 2003 Jul 16;290(3):374-80. doi: 10.1001/jama.290.3.374.
8
Effect of acute lung injury and acute respiratory distress syndrome on outcome in critically ill trauma patients.急性肺损伤和急性呼吸窘迫综合征对重症创伤患者预后的影响。
Crit Care Med. 2004 Feb;32(2):327-31. doi: 10.1097/01.CCM.0000108870.09693.42.
9
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008.拯救脓毒症运动:严重脓毒症和脓毒性休克治疗国际指南:2008年版
Crit Care Med. 2008 Jan;36(1):296-327. doi: 10.1097/01.CCM.0000298158.12101.41.
10
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.在流行地区,服用抗叶酸抗疟药物的人群中,叶酸补充剂与疟疾易感性和严重程度的关系。
Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217.

引用本文的文献

1
Influence of statin intervention on peripheral neuropathy in patients treated with anticancer drugs identified from the insurer database.从保险公司数据库中确定的他汀类药物干预对接受抗癌药物治疗患者周围神经病变的影响。
J Pharm Health Care Sci. 2025 Apr 7;11(1):27. doi: 10.1186/s40780-025-00428-3.
2
Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis.高脂血症与术后谵妄风险之间的关联:一项系统评价和荟萃分析。
Front Aging Neurosci. 2025 Mar 18;17:1544838. doi: 10.3389/fnagi.2025.1544838. eCollection 2025.
3
Effects of statins on the incidence and outcomes of acute kidney injury in critically ill patients: a systematic review and meta-analysis.

本文引用的文献

1
Oxidative stress.氧化应激。
JPEN J Parenter Enteral Nutr. 2012 Mar;36(2):147-54. doi: 10.1177/0148607111434963. Epub 2012 Feb 1.
2
Effects of methylprednisolone infusion on markers of inflammation, coagulation, and angiogenesis in early acute respiratory distress syndrome.甲泼尼龙输注对早期急性呼吸窘迫综合征炎症、凝血和血管生成标志物的影响。
Crit Care Med. 2012 Feb;40(2):495-501. doi: 10.1097/CCM.0b013e318232da5e.
3
Statins, vitamin D, and severe sepsis.他汀类药物、维生素D与严重脓毒症
他汀类药物对危重症患者急性肾损伤发生率及预后的影响:一项系统评价和荟萃分析。
Arch Med Sci. 2023 Jan 27;19(4):952-964. doi: 10.5114/aoms/159992. eCollection 2023.
4
The association of statins use with survival of patients with COVID-19.他汀类药物的使用与 COVID-19 患者生存的关系。
J Cardiol. 2022 Apr;79(4):494-500. doi: 10.1016/j.jjcc.2021.12.012. Epub 2021 Dec 22.
5
Peroxisome Proliferator-Activated Receptor Alpha Mediates the Beneficial Effects of Atorvastatin in Experimental Colitis.过氧化物酶体增殖物激活受体α介导阿托伐他汀在实验性结肠炎中的有益作用。
Front Immunol. 2021 Aug 9;12:618365. doi: 10.3389/fimmu.2021.618365. eCollection 2021.
6
Cardiovascular Pathophysiology, Epidemiology, and Treatment Considerations of Coronavirus Disease 2019 (COVID-19): A Review.2019年冠状病毒病(COVID-19)的心血管病理生理学、流行病学及治疗考量:综述
CJC Open. 2020 Sep 5;3(1):28-40. doi: 10.1016/j.cjco.2020.09.003. eCollection 2021 Jan.
7
Simvastatin Enhances the Immune Response Against .辛伐他汀增强针对……的免疫反应。 (原文句子不完整)
Front Microbiol. 2019 Sep 20;10:2097. doi: 10.3389/fmicb.2019.02097. eCollection 2019.
8
Statin use and Vital Organ Failure in Patients With Asthma-Chronic Obstructive Pulmonary Disease Overlap: A Time-Dependent Population-Based Study.哮喘-慢性阻塞性肺疾病重叠患者使用他汀类药物与重要器官衰竭:一项基于人群的时间依赖性研究
Front Pharmacol. 2019 Aug 16;10:889. doi: 10.3389/fphar.2019.00889. eCollection 2019.
9
Lipid profile and statin use in critical care setting: implications for kidney outcome.重症监护环境中的血脂谱与他汀类药物使用:对肾脏结局的影响
Einstein (Sao Paulo). 2019 May 30;17(3):eAO4399. doi: 10.31744/einstein_journal/2019AO4399.
10
A possible association between statin use and improved Clostridioides difficile infection mortality in veterans.他汀类药物的使用与退伍军人中艰难梭菌感染死亡率的降低有关。
PLoS One. 2019 May 28;14(5):e0217423. doi: 10.1371/journal.pone.0217423. eCollection 2019.
Eur J Intern Med. 2011 Aug;22(4):e25-6; author reply e27. doi: 10.1016/j.ejim.2011.04.001. Epub 2011 May 6.
4
Immunomodulatory agents in the treatment of community-acquired pneumonia: a systematic review.免疫调节剂在社区获得性肺炎治疗中的应用:系统评价。
J Infect. 2011 Sep;63(3):187-99. doi: 10.1016/j.jinf.2011.06.009. Epub 2011 Jul 5.
5
Understanding the potential role of statins in pneumonia and sepsis.了解他汀类药物在肺炎和脓毒症中的潜在作用。
Crit Care Med. 2011 Aug;39(8):1871-8. doi: 10.1097/CCM.0b013e31821b8290.
6
Effect of statin treatment on short term mortality after pneumonia episode: cohort study.肺炎发作后他汀类药物治疗对短期死亡率的影响:队列研究。
BMJ. 2011 Apr 6;342:d1642. doi: 10.1136/bmj.d1642.
7
Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome.院前使用他汀类药物和阿司匹林与严重脓毒症和急性肺损伤/急性呼吸窘迫综合征的患病率。
Crit Care Med. 2011 Jun;39(6):1343-50. doi: 10.1097/CCM.0b013e3182120992.
8
Clinical practice. Vitamin D insufficiency.临床实践。维生素D缺乏症。
N Engl J Med. 2011 Jan 20;364(3):248-54. doi: 10.1056/NEJMcp1009570.
9
Continuation of statin therapy in patients with presumed infection: a randomized controlled trial.他汀类药物治疗疑似感染患者的延续治疗:一项随机对照试验。
Am J Respir Crit Care Med. 2011 Mar 15;183(6):774-81. doi: 10.1164/rccm.201006-0955OC. Epub 2010 Oct 19.
10
A randomized clinical trial of hydroxymethylglutaryl- coenzyme a reductase inhibition for acute lung injury (The HARP Study).羟甲基戊二酰辅酶 A 还原酶抑制治疗急性肺损伤的随机临床试验(HARP 研究)。
Am J Respir Crit Care Med. 2011 Mar 1;183(5):620-6. doi: 10.1164/rccm.201003-0423OC. Epub 2010 Sep 24.