Cherstvoĭ E D, Siatkovskiĭ V A, Grigor'ev D G
Arkh Patol. 1990;52(9):51-6.
Dynamics of blood coagulation and morphological changes after the intravenous administration of Salmonella typhimurium endotoxin is studied experimentally in Chinchilla rabbits. The stages of blood coagulation are established characteristic for the above syndrome. The signs of the developing blood stasiopathy with the domination of vascular wall damage and thrombocyte aggregation are observed. No considerable consumption of the blood coagulation factors is found. It is concluded that a leading role in the pathogenesis of the endotoxin shock microcirculatory disturbances belongs to the vascular damage and aggregation thrombocytopenia and not to the coagulopathy consumption.
在实验中对青紫蓝兔静脉注射鼠伤寒沙门氏菌内毒素后血液凝固动力学及形态学变化进行了研究。确定了上述综合征特有的血液凝固阶段。观察到以血管壁损伤和血小板聚集为主的血液瘀滞病发展迹象。未发现血液凝固因子有大量消耗。得出结论，内毒素休克微循环障碍发病机制中的主导作用属于血管损伤和聚集性血小板减少，而非凝血病性消耗。
