Duke Clinical Research Institute, Duke University, Durham, NC, 27715, USA.
J Thromb Thrombolysis. 2012 Oct;34(3):410-5. doi: 10.1007/s11239-012-0760-4.
Budd-Chiari syndrome (BCS) or hepatic venous outflow obstruction, is a rare and complex clinical entity, with diverse aetiology and a wide range of presentations. Its rarity and heterogeneity create significant challenges for evidence-based clinical decision-making, particularly in the even more infrequent setting of acute BCS presentation. Here we present the case of a young woman with acute, severe BCS, where treatment alternatives were limited due to a significant IVC thrombus burden. A clearly defined acute onset allowed the prompt use of systemic thrombolysis, conducted in consultation with a multi-disciplinary team of clinicians, with close monitoring for both treatment response and complications. Her treatment resulted in resolution of hepatic vein occlusion and prevention of the potentially significant clinical sequelae. We review the literature and discuss current opinion in the management of BCS.
布加综合征（BCS）或肝静脉流出道阻塞是一种罕见且复杂的临床病症，具有多种病因和广泛的表现。其罕见性和异质性给基于证据的临床决策带来了重大挑战，特别是在更为罕见的急性 BCS 发作情况下更是如此。在此，我们报告了一例年轻女性的急性、严重 BCS 病例，由于下腔静脉血栓负荷显著，治疗选择受到限制。明确的急性发作允许及时使用全身性溶栓治疗，并与多学科临床医生团队进行协商，密切监测治疗反应和并发症。她的治疗导致肝静脉闭塞的消除，并预防了潜在的严重临床后果。我们回顾了文献并讨论了目前对 BCS 管理的意见。
