[The prognostic significance of estimation of levels of peripheral blood cytokines in patients with cervical neoplasms].

The article deals with the results of study of levels of peripheral blood cytokines in 156 patients with cervical intra epithelial neoplasia stage I, II and III associated with human papilloma virus. The levels of cytokines didn't undergo significant alterations in patients with cervical intra epithelial neoplasia stage I. The progress of cervical intra epithelial neoplasia stage II was accompanied with increasing of levels of interferon (gamma), interleukin 10 and tumor necrosis factor (alpha). The severe dysplasia was characterized by decreasing of levels of cytokines mentioned above. The study results testify the important role was cytokines determining the progression of neoplastic process conditioned by papilloma virus infection.