[子宫癌肉瘤：分子遗传学和形态学特征]

[Carcinosarcomas of the uterus: molecular-genetic and morphological features].

作者信息

Levitskaia N V, Pozharisskiĭ K M, Vostriukhina O A, Alekseeva L N, Nemtsova M V, Matrosova I V, Kharitonova T V, Poddubnaia I V

出版信息

Arkh Patol. 2012 Jan-Feb;74(1):7-11.

PMID:22712296

Abstract

13 cases of uterine carcinosarcomas have been studied by molecular-genetic method. The impairment of some genes (K-RAS gene in the first exon, TP53 in the 5th-9th exons, PTEN in the 5th and 8th exons) has been found out. The loss of heterozygosity of TP53 gene in epithelium and mesenchyme of the uterus has been detected. According to the estimation of impairment the studied tumors was divided into monoclonal and biclonal ones. This stratification could be use as prognostic criteria of uterine carcinosarcomas clinical presentation.

摘要

采用分子遗传学方法对13例子宫癌肉瘤进行了研究。发现了一些基因（第1外显子中的K-RAS基因、第5至9外显子中的TP53基因、第5和8外显子中的PTEN基因）的损伤。检测到子宫上皮和间充质中TP53基因的杂合性缺失。根据损伤评估，将所研究的肿瘤分为单克隆和双克隆肿瘤。这种分层可作为子宫癌肉瘤临床表现的预后标准。