Zhao Qin, Sun Yani, Zhou Enmin
Veterinary Immunology Research Institute, College of Veterinary Medicine, Northwest A & F University, Yangling 712100, China.
Wei Sheng Wu Xue Bao. 2012 Mar 4;52(3):279-85.
Avian hepatitis E virus (HEV), a member of Hepeviridae family, is genetically and antigenically related with human and swine HEV in the family. Since its discovery, avian HEV infection has been investigated in many countries from serology and molecular epidemiology studies. At present, five complete or near complete genomes of avian HEV isolates were reported in GenBank and were divided into three genotypes. The complete genome of avian HEV contains 3 ORFs of which ORF2 gene encodes capsid protein containing the primary epitopes of viral particles and is target gene for serodiagnostic antigen and vaccine candidate. Because avian HEV infection has significant impact on the poultry industry and potential zoonotic transmission, the researches on avian HEV have been given much attention. We here give a broad review of the research update on the aetiology, pathogenesis and the antigenicity of capsid protein of avian HEV based on identification of Chinese avian HEV isolate.
禽戊型肝炎病毒（HEV）是肝炎病毒科的成员，在基因和抗原方面与该科的人类和猪HEV相关。自发现以来，已通过血清学和分子流行病学研究在许多国家对禽HEV感染进行了调查。目前，GenBank中报告了5个禽HEV分离株的完整或近乎完整的基因组，并分为3个基因型。禽HEV的完整基因组包含3个开放阅读框（ORF），其中ORF2基因编码含有病毒颗粒主要表位的衣壳蛋白，是血清学诊断抗原和候选疫苗的靶基因。由于禽HEV感染对家禽业有重大影响且存在潜在的人畜共患病传播，因此对禽HEV的研究备受关注。在此，我们基于中国禽HEV分离株的鉴定，对禽HEV的病因、发病机制和衣壳蛋白抗原性的研究进展进行全面综述。
