Department of Gastroenterology & Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
J Dig Dis. 2012 Jul;13(7):337-41. doi: 10.1111/j.1751-2980.2012.00605.x.
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of the biliary tract leading to progressive obstruction, fibrosis and eventually liver cirrhosis. In some countries it ranks among the most frequent indications for liver transplantation. PSC is also a carcinogenic condition in which the risk of hepatobiliary carcinoma, especially cholangiocarcinoma, is greatly increased. Patients with associated inflammatory bowel disease involving the colon run an increased risk of colorectal carcinoma. Currently, there is no medical therapy with a proven benefit in halting disease progression.
原发性硬化性胆管炎（PSC）是一种慢性胆道炎症性疾病，可导致进行性胆道梗阻、纤维化，最终发展为肝硬化。在一些国家，它是肝移植最常见的适应证之一。PSC 也是一种致癌疾病，肝胆癌的风险，特别是胆管癌的风险大大增加。伴有累及结肠的炎症性肠病的患者发生结直肠癌的风险增加。目前，尚无经证实可阻止疾病进展的有效医学治疗方法。
