IRGM 基因多态性与胃癌风险。

IRGM gene polymorphisms and risk of gastric cancer.

机构信息

Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy from Craiova, Craiova, Romania.

出版信息

J Dig Dis. 2012 Jul;13(7):360-5. doi: 10.1111/j.1751-2980.2012.00602.x.

DOI:10.1111/j.1751-2980.2012.00602.x

PMID:22713085

Abstract

OBJECTIVE

The study aimed to assess the possible association of polymorphisms in the autophagy gene IRGM (rs13361189 and rs4958847) with the risk of gastric cancer.

METHODS

A total of 102 patients with gastric adenocarcinoma, 52 with chronic gastritis and 351 healthy controls were included in this study. IRGM allelic variants were genotyped by quantitative real-time polymerase chain reaction. The association between polymorphisms and gastric cancer risk was estimated by odds ratios (OR) and 95% confidence interval (CI).

RESULTS

A significant difference was found for rs4958847 A allele. Carriers of the A allele were protected against gastric cancer (OR = 0.58, 95% CI 0.35-0.97, P = 0.038). Moreover, the presence of this allele seems to play an important role in decreasing the risk for the intestinal type of gastric cancer (OR = 0.47, 95% CI 0.23-0.94, P = 0.03). In contrast, the rs13361189 IRGM polymorphism was not associated with susceptibility to gastric cancer. None of the targeted polymorphisms were associated with chronic gastritis.

CONCLUSION

IRGM rs4958847 polymorphism influences susceptibility to gastric cancer, mainly for the intestinal type.

摘要

目的

本研究旨在评估自噬基因 IRGM（rs13361189 和 rs4958847）多态性与胃癌风险之间的可能关联。

方法

本研究共纳入 102 例胃腺癌患者、52 例慢性胃炎患者和 351 例健康对照者。采用实时定量聚合酶链反应检测 IRGM 等位基因变异。通过比值比（OR）和 95%置信区间（CI）评估多态性与胃癌风险之间的关联。

结果

rs4958847A 等位基因存在显著差异。携带 A 等位基因的个体患胃癌的风险较低（OR=0.58，95%CI0.35-0.97，P=0.038）。此外，该等位基因的存在似乎在降低肠型胃癌的风险方面发挥着重要作用（OR=0.47，95%CI0.23-0.94，P=0.03）。相比之下，rs13361189IRGM 多态性与胃癌易感性无关。未发现目标多态性与慢性胃炎有关。