Laboratory for Animal Sciences, Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India.
J Sci Food Agric. 2013 Jan;93(2):422-6. doi: 10.1002/jsfa.5762. Epub 2012 Jun 20.
Limonia fruit pulp is edible and used in a number of food preparations. This fruit is also used as a folk medicine to treat various ailments and reportedly possesses antihyperglycaemic and antihyperlipidaemic activities. The purpose of the present study was to examine the potential of Limonia acidissima L. (LA) fruit pulp in regulating the carbohydrate and lipid profiles in fluoride-exposed rats.
Exposure to fluoride (100 mg l⁻¹ NaF) resulted in significant increases in plasma and hepatic carbohydrate and lipid profiles. Administration of LA fruit powder (2.5, 5 and 10 g kg⁻¹) in the diet for 4 weeks resulted in significant decreases in plasma glucose and lipid profiles and hepatic glucose-6-phosphatase activity and significant increases in hepatic glycogen content and hexokinase activity and plasma high-density lipoprotein cholesterol. Phytochemical analysis of the LA fruit pulp revealed the presence of fibres, phytosterols, saponins, polyphenols, flavonoids and ascorbic acid.
Consumption of LA fruit pulp is beneficial in controlling hyperglycaemia and hyperlipidaemia in fluoride-induced toxicity. Since fibres, phytosterols, saponins, polyphenols, flavonoids and total ascorbic acid are known to influence both carbohydrate and lipid metabolisms, the decline in carbohydrate and lipid levels in LA-administered fluoride-exposed rats could be attributed to the phytoconstituents of the fruit.
酸橙果肉可食用，用于多种食品制备。这种水果也被用作民间药物来治疗各种疾病，据报道具有降血糖和降血脂的作用。本研究的目的是研究酸橙（Limonia acidissima L.）果肉在调节氟暴露大鼠糖和脂谱中的潜力。
暴露于氟（100mg l⁻¹ NaF）导致血浆和肝糖和脂质谱显著增加。在饮食中连续 4 周给予 LA 果粉（2.5、5 和 10g kg⁻¹），可显著降低血浆葡萄糖和脂质谱以及肝葡萄糖-6-磷酸酶活性，显著增加肝糖原含量和己糖激酶活性以及血浆高密度脂蛋白胆固醇。LA 果肉的植物化学分析表明存在纤维、植物甾醇、皂甙、多酚、类黄酮和抗坏血酸。
食用 LA 果肉有益于控制氟化物诱导的毒性引起的高血糖和高血脂。由于纤维、植物甾醇、皂甙、多酚、类黄酮和总抗坏血酸已知影响碳水化合物和脂质代谢，因此在 LA 给药的氟暴露大鼠中碳水化合物和脂质水平的下降可能归因于水果的植物成分。
