Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Cancer Epidemiol Biomarkers Prev. 2012 Aug;21(8):1385-7. doi: 10.1158/1055-9965.EPI-12-0600. Epub 2012 Jun 19.
Although the role of miRNA in cancer development and progression has been well established, the association between genetic variants in miRNA biogenesis pathway genes and breast cancer risk has been yet unclear.
We analyzed data from two genome-wide association studies conducted in East Asian women including 5,066 cases and 4,337 controls. Among the single-nucleotide polymorphisms (SNP), which were directly genotyped or imputed, we selected 237 SNPs in 32 genes involved in miRNA biogenesis pathway and its regulation.
Although eight SNPs were nominally associated with breast cancer risk in combined samples (P < 0.05), none of them were significant after adjustment for multiple comparisons.
The common genetic variants in miRNA biogenesis pathway genes may not be associated with breast cancer risk.
This study suggests no association between the polymorphisms in miRNA biogenesis pathway genes and breast cancer risk. Studies with large sample size and more genetic variants should be warranted to adequately evaluate the potential association.
尽管 miRNA 在癌症发生和发展中的作用已得到充分证实，但 miRNA 生物发生途径基因中的遗传变异与乳腺癌风险之间的关联尚不清楚。
我们分析了两项在东亚女性中进行的全基因组关联研究的数据，包括 5066 例病例和 4337 例对照。在直接基因分型或推断的单核苷酸多态性（SNP）中，我们选择了 miRNA 生物发生途径及其调节中涉及的 32 个基因中的 237 个 SNP。
尽管在合并样本中，有 8 个 SNP 与乳腺癌风险呈显著相关（P < 0.05），但在进行多次比较调整后，没有一个 SNP 具有统计学意义。
miRNA 生物发生途径基因中的常见遗传变异可能与乳腺癌风险无关。需要更大的样本量和更多遗传变异的研究来充分评估潜在的关联。
