Radulović P, Kraus O, Krušlin B
Ljudevit Jurak University, Department of Pathology, zagreb, Croatia.
Cesk Patol. 2012 Apr;48(2):100-2.
Micropapillary urothelial carcinoma (MPUC) is a rare aggressive variant of urothelial carcinoma, associated with advanced tumor stage, high tendency to invade lymphovascular spaces, and metastasize to lymph nodes and other organs. Therefore, it has a poor prognosis. One of the most prominent histological features is the presence of small, round empty spaces surrounding infiltrating tumor nests. If detected, even a small focus of micropapillary pattern may be therapeutically significant; the higher proportion of micropapillary component, the worse the prognosis. Radical nephroureterectomy is the treatment of choice even in the setting of superficially invasive disease. Although, MPUC has been well studied in urinary bladder, only a few cases of MPUC in upper urinary tract have been described. We are describing a case of a 79-year old woman with micropapillary urothelial carcinoma involving ureter and review the literature of this rare entity.
微乳头型尿路上皮癌（MPUC）是尿路上皮癌一种罕见的侵袭性变体，与肿瘤晚期、侵犯淋巴血管间隙及转移至淋巴结和其他器官的倾向性高相关。因此，其预后较差。最显著的组织学特征之一是浸润性肿瘤巢周围存在小的圆形空隙。一旦发现，即使是小灶的微乳头模式在治疗上也可能具有重要意义；微乳头成分比例越高，预后越差。根治性肾输尿管切除术即使在浅表浸润性疾病情况下也是首选治疗方法。虽然MPUC在膀胱中已有充分研究，但上尿路MPUC仅有少数病例报道。我们现报道一例79岁女性微乳头型尿路上皮癌累及输尿管的病例，并复习有关这一罕见实体的文献。
