Gurkalo V K, Tret'iakov A V
Vopr Med Khim. 1979 Sep-Oct;25(5):540-3.
Distinct increase in activity of uridine kinase and pronounced decrease in thymidine kinase activity were observed in cell-free extracts of rat liver tissue at early stages of hepatocarcinogenesis caused by administration of N-nitrose diethylamine and 2-acetyl aminofluorene. Exogenous noradrepaline did not affect the altered activity of thymidine kinase but stimulated the effect of N-nitrose diethylamine and lowered the effect of 2-acetyl aminofluorene on the urindine kinase activity. Adrenergic neurotransmitters appear to influence the cell proliferation due to modification of the enzymes participating in the synthesis of nucleic acid precursors.
在给予N-亚硝基二乙胺和2-乙酰氨基芴诱导大鼠肝癌发生的早期阶段，在大鼠肝组织的无细胞提取物中观察到尿苷激酶活性明显增加，胸苷激酶活性显著降低。外源性去甲肾上腺素不影响胸苷激酶的改变活性，但刺激了N-亚硝基二乙胺的作用，并降低了2-乙酰氨基芴对尿苷激酶活性的影响。肾上腺素能神经递质似乎通过参与核酸前体合成的酶的修饰来影响细胞增殖。
