Formicka-Kozłowska G, Kozłowski H, Jezowska-Trzebiatowska B
Acta Biochim Pol. 1979;26(3):239-48.
The interaction of copper(II), nickel(II) and cobalt(II) ions with oxidized glutathione in aqueous solutions have been examined by spectroscopic methods. Cu(II) is the only ion which interacts with disulphide bridge and forms dimeric species containing the Cu(II)-S-S-Cu(II) unit. Ni(II) and Co(II) bind mainly with the terminal NH2 and COO- groups of glutamic acid, and the complexes formed are of nearly octahedral symmetry. At high pH, in the Co(II)-GSSG solution Co(II) is oxidized to Co(III) with the concomitant reduction of GSSG to GSH. Considerable differences were observed between the oxidized and reduced form of glutathione in the coordination ability towards metal ions.
采用光谱法研究了水溶液中铜（II）、镍（II）和钴（II）离子与氧化型谷胱甘肽的相互作用。铜（II）是唯一能与二硫键相互作用并形成含有Cu（II）-S-S-Cu（II）单元的二聚体物种的离子。镍（II）和钴（II）主要与谷氨酸的末端NH2和COO-基团结合，形成的配合物具有近似八面体对称性。在高pH值下，在Co（II）-GSSG溶液中，Co（II）被氧化为Co（III），同时GSSG被还原为GSH。观察到谷胱甘肽的氧化型和还原型在与金属离子的配位能力上存在显著差异。
