研究 BDNF 转运和活动依赖性释放的多种方法及其在神经遗传疾病中的应用。
Multiple approaches to investigate the transport and activity-dependent release of BDNF and their application in neurogenetic disorders.
机构信息
Department of Neurobiology, SHEL 1002, Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294-2182, USA.
出版信息
Neural Plast. 2012;2012:203734. doi: 10.1155/2012/203734. Epub 2012 Jun 6.
Abstract
Studies utilizing genetic and pharmacological manipulations in rodent models and neuronal cultures have revealed myriad roles of brain-derived neurotrophic factor (BDNF). Currently, this knowledge of BDNF function is being translated into improvement strategies for several debilitating neurological disorders in which BDNF abnormalities play a prominent role. Common among the BDNF-related disorders are irregular trafficking and release of mature BDNF (mBDNF) and/or its prodomain predecessor, proBDNF. Thus, investigating the conditions required for proper trafficking and release of BDNF is an essential step toward understanding and potentially improving these neurological disorders. This paper will provide examples of disorders related to BDNF release and serve as a review of the techniques being used to study the trafficking and release of BDNF.
摘要
利用遗传和药理学手段在啮齿动物模型和神经元培养物中的研究揭示了脑源性神经营养因子（BDNF）的众多作用。目前，BDNF 功能的这方面知识正在被转化为几种使人衰弱的神经紊乱的改善策略，在这些紊乱中，BDNF 异常起着突出的作用。BDNF 相关紊乱的共同点是成熟 BDNF（mBDNF）及其前体原 BDNF 的异常运输和释放。因此，研究正确运输和释放 BDNF 的条件是理解和潜在改善这些神经紊乱的重要步骤。本文将提供与 BDNF 释放相关的紊乱的实例，并综述用于研究 BDNF 运输和释放的技术。
相似文献
1
Multiple approaches to investigate the transport and activity-dependent release of BDNF and their application in neurogenetic disorders.
Neural Plast. 2012;2012:203734. doi: 10.1155/2012/203734. Epub 2012 Jun 6.
2
Development of mature BDNF-specific sandwich ELISA.
J Neurochem. 2015 Jul;134(1):75-85. doi: 10.1111/jnc.13108. Epub 2015 Apr 21.
3
Brain Derived Neurotrophic Factor: a novel neurotrophin involved in psychiatric and neurological disorders.
Pharmacol Ther. 2012 Apr;134(1):116-24. doi: 10.1016/j.pharmthera.2012.01.006. Epub 2012 Jan 20.
4
Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.
J Biol Chem. 2011 Aug 26;286(34):29556-67. doi: 10.1074/jbc.M111.219675. Epub 2011 Jul 5.
5
New insights in the biology of BDNF synthesis and release: implications in CNS function.
J Neurosci. 2009 Oct 14;29(41):12764-7. doi: 10.1523/JNEUROSCI.3566-09.2009.
6
Analysis of blood mature BDNF and proBDNF in mood disorders with specific ELISA assays.
J Psychiatr Res. 2021 Jan;133:166-173. doi: 10.1016/j.jpsychires.2020.12.021. Epub 2020 Dec 13.
7
Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurodegenerative diseases.
Brain Res Bull. 2021 Jan;166:172-184. doi: 10.1016/j.brainresbull.2020.11.005. Epub 2020 Nov 14.
8
Effects of corticosterone on the expression of mature brain-derived neurotrophic factor (mBDNF) and proBDNF in the hippocampal dentate gyrus.
Behav Brain Res. 2019 Jun 3;365:150-156. doi: 10.1016/j.bbr.2019.03.010. Epub 2019 Mar 6.
9
Investigation of Mature BDNF and proBDNF Signaling in a Rat Photothrombotic Ischemic Model.
Neurochem Res. 2018 Mar;43(3):637-649. doi: 10.1007/s11064-017-2464-9. Epub 2018 Jan 12.
10
Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease.
Neurobiol Dis. 2015 Oct;82:466-477. doi: 10.1016/j.nbd.2015.08.008. Epub 2015 Aug 15.
引用本文的文献
1
A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice.
Dis Model Mech. 2024 Jun 1;17(6). doi: 10.1242/dmm.050612. Epub 2024 May 24.
2
Optimal Intervention Timing for Robotic-Assisted Gait Training in Hemiplegic Stroke.
Brain Sci. 2022 Aug 10;12(8):1058. doi: 10.3390/brainsci12081058.
3
The acute effects of aerobic exercise on sensorimotor adaptation in chronic stroke.
Restor Neurol Neurosci. 2021;39(5):367-377. doi: 10.3233/RNN-211175.
4
Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington's Disease.
Sci Rep. 2018 Nov 19;8(1):16976. doi: 10.1038/s41598-018-34883-w.
5
The Effect of Aerobic Exercise on Brain-Derived Neurotrophic Factor in People with Neurological Disorders: A Systematic Review and Meta-Analysis.
Neural Plast. 2017;2017:4716197. doi: 10.1155/2017/4716197. Epub 2017 Sep 19.
6
The val-66-met Polymorphism Affects Neuronal Morphology and Synaptic Transmission in Cultured Hippocampal Neurons from Rett Syndrome Mice.
Front Cell Neurosci. 2017 Jul 13;11:203. doi: 10.3389/fncel.2017.00203. eCollection 2017.
7
A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome.
Front Cell Neurosci. 2014 Mar 7;8:68. doi: 10.3389/fncel.2014.00068. eCollection 2014.
8
BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin.
J Neurosci. 2014 Jan 15;34(3):963-8. doi: 10.1523/JNEUROSCI.2700-13.2014.
9
Involvement of TrkB- and p75(NTR)-signaling pathways in two contrasting forms of long-lasting synaptic plasticity.
Sci Rep. 2013 Nov 11;3:3185. doi: 10.1038/srep03185.
本文引用的文献
1
Complexities of Rett syndrome and MeCP2.
J Neurosci. 2011 Jun 1;31(22):7951-9. doi: 10.1523/JNEUROSCI.0169-11.2011.
2
Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene.
J Neurosci. 2011 Mar 2;31(9):3295-308. doi: 10.1523/JNEUROSCI.4540-10.2011.
3
Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing.
J Biol Chem. 2011 May 6;286(18):16272-84. doi: 10.1074/jbc.M110.195347. Epub 2011 Feb 28.
4
Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease.
Cell Death Differ. 2011 Feb;18(2):191-200. doi: 10.1038/cdd.2010.127. Epub 2010 Nov 19.
5
Huntington's disease: a clinical review.
Orphanet J Rare Dis. 2010 Dec 20;5:40. doi: 10.1186/1750-1172-5-40.
6
Dendritic spine abnormalities in mental retardation.
Cell Tissue Res. 2010 Dec;342(3):317-23. doi: 10.1007/s00441-010-1070-9. Epub 2010 Nov 16.
7
A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.
Cell. 2010 Nov 12;143(4):527-39. doi: 10.1016/j.cell.2010.10.016.
8
BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse.
Neurobiol Dis. 2011 Feb;41(2):469-80. doi: 10.1016/j.nbd.2010.10.018. Epub 2010 Nov 1.
9
Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome.
Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18161-6. doi: 10.1073/pnas.1005595107. Epub 2010 Oct 4.
10
Blood BDNF concentrations reflect brain-tissue BDNF levels across species.
Int J Neuropsychopharmacol. 2011 Apr;14(3):347-53. doi: 10.1017/S1461145710000738. Epub 2010 Jul 7.
Zotero 插件