Department of Neurobiology, SHEL 1002, Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294-2182, USA.
Neural Plast. 2012;2012:203734. doi: 10.1155/2012/203734. Epub 2012 Jun 6.
Studies utilizing genetic and pharmacological manipulations in rodent models and neuronal cultures have revealed myriad roles of brain-derived neurotrophic factor (BDNF). Currently, this knowledge of BDNF function is being translated into improvement strategies for several debilitating neurological disorders in which BDNF abnormalities play a prominent role. Common among the BDNF-related disorders are irregular trafficking and release of mature BDNF (mBDNF) and/or its prodomain predecessor, proBDNF. Thus, investigating the conditions required for proper trafficking and release of BDNF is an essential step toward understanding and potentially improving these neurological disorders. This paper will provide examples of disorders related to BDNF release and serve as a review of the techniques being used to study the trafficking and release of BDNF.
利用遗传和药理学手段在啮齿动物模型和神经元培养物中的研究揭示了脑源性神经营养因子（BDNF）的众多作用。目前，BDNF 功能的这方面知识正在被转化为几种使人衰弱的神经紊乱的改善策略，在这些紊乱中，BDNF 异常起着突出的作用。BDNF 相关紊乱的共同点是成熟 BDNF（mBDNF）及其前体原 BDNF 的异常运输和释放。因此，研究正确运输和释放 BDNF 的条件是理解和潜在改善这些神经紊乱的重要步骤。本文将提供与 BDNF 释放相关的紊乱的实例，并综述用于研究 BDNF 运输和释放的技术。
