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Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice.奥沙利铂联合肝脏特异性表达白细胞介素 12 减少肿瘤免疫抑制微环境并根除小鼠转移性结直肠癌。
Gut. 2011 Mar;60(3):341-9. doi: 10.1136/gut.2010.211722. Epub 2010 Sep 20.
2
5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity.5-氟尿嘧啶选择性杀死肿瘤相关的髓系来源的抑制性细胞，从而增强 T 细胞依赖性抗肿瘤免疫。
Cancer Res. 2010 Apr 15;70(8):3052-61. doi: 10.1158/0008-5472.CAN-09-3690. Epub 2010 Apr 13.
3
Immunogenic death of colon cancer cells treated with oxaliplatin.奥沙利铂处理的结肠癌细胞的免疫原性死亡。
Oncogene. 2010 Jan 28;29(4):482-91. doi: 10.1038/onc.2009.356. Epub 2009 Nov 2.
4
Myeloid-derived suppressor cells as regulators of the immune system.髓源性抑制细胞作为免疫系统的调节因子。
Nat Rev Immunol. 2009 Mar;9(3):162-74. doi: 10.1038/nri2506.
5
Molecular interactions between dying tumor cells and the innate immune system determine the efficacy of conventional anticancer therapies.垂死的肿瘤细胞与先天免疫系统之间的分子相互作用决定了传统抗癌疗法的疗效。
Cancer Res. 2008 Jun 1;68(11):4026-30. doi: 10.1158/0008-5472.CAN-08-0427.
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Interleukin-12 inhibits liver-specific drug-inducible systems in vivo.白细胞介素-12在体内抑制肝脏特异性药物诱导系统。
Gene Ther. 2008 Feb;15(4):277-88. doi: 10.1038/sj.gt.3303073. Epub 2007 Nov 22.
7
Interleukin-12: biological properties and clinical application.白细胞介素-12：生物学特性与临床应用
Clin Cancer Res. 2007 Aug 15;13(16):4677-85. doi: 10.1158/1078-0432.CCR-07-0776.
8
Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity.吉西他滨可选择性清除荷瘤动物脾脏中的Gr-1+/CD11b+髓源性抑制细胞，并增强抗肿瘤免疫活性。
Clin Cancer Res. 2005 Sep 15;11(18):6713-21. doi: 10.1158/1078-0432.CCR-05-0883.
9
Prolonged and inducible transgene expression in the liver using gutless adenovirus: a potential therapy for liver cancer.使用无肠腺病毒在肝脏中实现长期且可诱导的转基因表达：一种潜在的肝癌治疗方法。
Gastroenterology. 2004 Jan;126(1):278-89. doi: 10.1053/j.gastro.2003.10.075.
10
Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons.辅助依赖型腺病毒载体的给药及不同载体血清型的序贯递送用于狒狒的长期肝靶向基因转移
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12816-21. doi: 10.1073/pnas.96.22.12816.

基因转染白细胞介素-12 联合奥沙利铂免疫化学疗法治疗结肠癌。

Immunochemotherapy against colon cancer by gene transfer of interleukin-12 in combination with oxaliplatin.

机构信息

Division of Gene Therapy and Hepatology; CIMA, University of Navarra; Foundation for Applied Medical Research; Pamplona, Spain.

出版信息

Oncoimmunology. 2012 Jan 1;1(1):97-99. doi: 10.4161/onci.1.1.17930.

DOI:10.4161/onci.1.1.17930
PMID:22720223
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3376956/
Abstract

Using a murine model of liver metastases, we found that oxaliplatin can enhance the immunostimulatory effect of interleukin-12 delivered by an adenoviral vector. A shift toward a favorable immune microenvironment was observed in tumors, with a relative increase in CD8+ T cells vs. T regulatory and myeloid-derived suppressor cells.

摘要

在一个肝脏转移的鼠模型中，我们发现奥沙利铂可以增强腺病毒载体传递的白细胞介素-12 的免疫刺激作用。在肿瘤中观察到有利于免疫微环境的转变，CD8+T 细胞相对于 T 调节细胞和髓源性抑制细胞相对增加。