基因转染白细胞介素-12 联合奥沙利铂免疫化学疗法治疗结肠癌。
Immunochemotherapy against colon cancer by gene transfer of interleukin-12 in combination with oxaliplatin.
机构信息
Division of Gene Therapy and Hepatology; CIMA, University of Navarra; Foundation for Applied Medical Research; Pamplona, Spain.
出版信息
Oncoimmunology. 2012 Jan 1;1(1):97-99. doi: 10.4161/onci.1.1.17930.
Abstract
Using a murine model of liver metastases, we found that oxaliplatin can enhance the immunostimulatory effect of interleukin-12 delivered by an adenoviral vector. A shift toward a favorable immune microenvironment was observed in tumors, with a relative increase in CD8+ T cells vs. T regulatory and myeloid-derived suppressor cells.
摘要
在一个肝脏转移的鼠模型中，我们发现奥沙利铂可以增强腺病毒载体传递的白细胞介素-12 的免疫刺激作用。在肿瘤中观察到有利于免疫微环境的转变，CD8+T 细胞相对于 T 调节细胞和髓源性抑制细胞相对增加。
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本文引用的文献
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5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity.5-氟尿嘧啶选择性杀死肿瘤相关的髓系来源的抑制性细胞，从而增强 T 细胞依赖性抗肿瘤免疫。
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