Department of Immunology and Oncology; Centro Nacional de Biotecnología-CSIC; UAM Campus Cantoblanco; Madrid, Spain.
Oncoimmunology. 2012 Mar 1;1(2):195-200. doi: 10.4161/onci.1.2.18613.
The discovery of a stem cell population in human neoplasias has given a new impulse to the study of the origins of cancer. The tissue compartment in which transformation first occurs likely comprises stem cells, since these cells need to consolidate the short-term and long-term requisites of tissue renewal. Because of their unique role, stem cells have a combination of characteristics that makes them susceptible to genetic damage, transformation, and tumor initiation. One type of genetic damage in particular, chromosomal instability, might affect the stem cell compartment, because it induces an ongoing cycle of DNA damage and alters cellular programming. Here, we will discuss some of the recently described links between SC, chromosomal instability, and carcinogenesis, and outline some of the consequences for oncoimmunology.
人类肿瘤中干细胞群体的发现，为癌症起源的研究带来了新的动力。发生转化的组织区室可能包含干细胞，因为这些细胞需要巩固组织更新的短期和长期需求。由于其独特的作用，干细胞具有使它们易受遗传损伤、转化和肿瘤起始的特征组合。特别是一种遗传损伤，染色体不稳定性，可能会影响干细胞区室，因为它会导致持续的 DNA 损伤循环，并改变细胞编程。在这里，我们将讨论最近描述的 SC、染色体不稳定性和致癌作用之间的一些联系，并概述其对肿瘤免疫学的一些影响。
