实验性神经胶质瘤的间质化疗

Interstitial chemotherapy of experimental gliomas.

作者信息

Zeller W J, Bauer S, Remmele T, Wowra B, Sturm V, Stricker H

机构信息

Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.

出版信息

Cancer Treat Rev. 1990 Sep;17(2-3):183-9. doi: 10.1016/0305-7372(90)90045-h.

DOI:10.1016/0305-7372(90)90045-h

PMID:2272032

Abstract

Two new approaches of interstitial (intratumoral) chemotherapy of gliomas are presented. Using s.c.-transplanted rat gliomas (G616) the therapeutic activity of biologically degradable polylactide rods as carriers for methotrexate was investigated. Carrier-mediated intratumoral chemotherapy was superior both to a systemic treatment and an intratumoral treatment with the free drug. The activity of the alkyllysophospholipids Et-18-OCH3 and BM 41.440 and of the alkylphosphocholine He-PC was investigated in a human glioma xenograft (T 406). All three compounds were highly active following intratumoral administration.

摘要

本文介绍了两种新的胶质瘤间质（瘤内）化疗方法。利用皮下移植的大鼠胶质瘤（G616），研究了可生物降解的聚丙交酯棒作为甲氨蝶呤载体的治疗活性。载体介导的瘤内化疗优于全身治疗和游离药物的瘤内治疗。在人胶质瘤异种移植物（T 406）中研究了烷基溶血磷脂Et-18-OCH3和BM 41.440以及烷基磷胆碱He-PC的活性。瘤内给药后，所有这三种化合物都具有高活性。