Mc Avinchey Grainne, Swinson Brian
Department of Maxillofacial Surgery, Altnagelvin Area Hospital, Glenshane Road, Londonderry BT47 6SB, UK.
Dent Update. 2012 Jan-Feb;39(1):33-4, 37. doi: 10.12968/denu.2012.39.1.33.
Warfarin is an oral anticoagulant, used routinely for patients with atrial fibrillation, deep vein thrombosis, pulmonary embolism and those with a mechanical prosthetic valve. There are several noted adverse reactions associated with its use, in particular the risk of haemorrhage. Other adverse reactions include: hypersensitivity, rash, alopecia, diarrhoea, unexplained drop in haematocrit, purple toes, skin necrosis, jaundice, hepatic dysfunction, nausea, vomiting and pancreatitis. In this case report, an interesting potential adverse reaction to warfarin is discussed. The reaction described affected the patient's tongue, without affecting any other aspect of the oral cavity or body.
This case report highlights the potential problems that can be encountered by patients on warfarin therapy, specifically, the possibility for hypersensitivity type reactions.
华法林是一种口服抗凝剂,常用于心房颤动、深静脉血栓形成、肺栓塞患者以及植入机械人工瓣膜的患者。使用华法林有几种已知的不良反应,特别是出血风险。其他不良反应包括:过敏反应、皮疹、脱发、腹泻、不明原因的血细胞比容下降、紫色脚趾、皮肤坏死、黄疸、肝功能障碍、恶心、呕吐和胰腺炎。在本病例报告中,讨论了对华法林一种有趣的潜在不良反应。所描述的反应影响了患者的舌头,而未影响口腔或身体的任何其他部位。
本病例报告强调了接受华法林治疗的患者可能遇到的潜在问题,具体而言,即过敏反应类型的可能性。