Cavagnini F, Di Landro A, Maraschini C, Invitti C, Pinto M L
Acta Endocrinol (Copenh). 1979 Aug;91(4):666-73. doi: 10.1530/acta.0.0910666.
The aim of this study was to investigate the possible role of prostaglandins (PG) in the control of the hypohtalamic-pituitary-adrenocortical axis in normal volunteers. Acute oral administration of 100 mg indomethacin (ID) or 1.5 g acetylsalicylic acid (ASA) did not alter ACTH and cortisol plasma levels. Administration of 300 mg daily ID for 4 days delayed the onset, but increased the magnitude, of the response of ACTH to insulin hypoglycaemia, while it blunted the cortisol response. Administration of 3.2 g ASA daily depressed ACTH response to hypoglycaemia leaving the cortisol response unchanged, except for a 15 min delay in onset. These results are interpreted assuming that ID and ASA chiefly acted at the pituitary and hypothalamic level, respectively, and that ID, but not ASA, interfered with adrenocortical cortisol production. Our findings support the concept, based on animal studies, that PG enhance hypothalamic CRF release and adrenocortical steroidogenesis and may restrain ACTH secretion in the pituitary.
本研究的目的是调查前列腺素（PG）在正常志愿者下丘脑-垂体-肾上腺皮质轴调控中可能发挥的作用。急性口服100毫克吲哚美辛（ID）或1.5克乙酰水杨酸（ASA）并未改变促肾上腺皮质激素（ACTH）和皮质醇的血浆水平。连续4天每天服用300毫克ID延迟了ACTH对胰岛素低血糖反应的起始时间，但增加了反应幅度，同时减弱了皮质醇反应。每天服用3.2克ASA会抑制ACTH对低血糖的反应，皮质醇反应保持不变，只是起始时间延迟了15分钟。这些结果的解释是，假设ID和ASA分别主要作用于垂体和下丘脑水平，且ID而非ASA会干扰肾上腺皮质皮质醇的产生。我们的研究结果支持了基于动物研究的概念，即PG可增强下丘脑促肾上腺皮质激素释放因子（CRF）的释放和肾上腺皮质类固醇生成，并可能抑制垂体中ACTH的分泌。
