Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Int J Neurosci. 2012 Nov;122(11):650-6. doi: 10.3109/00207454.2012.704454. Epub 2012 Jul 12.
Both multiple sclerosis (MS) and neuro-Behcet's disease (NBD) can cause a cognitive dysfunction mainly involving the executive functions. We conducted this study to clarify the probable differential cognitive/behavioral profiles of MS and NBD. Twenty consecutive cases with parenchymal NBD (13 male, seven female), and 20 cases with MS (five male, 15 female) were evaluated. Both groups had a thorough neurological examination; an evaluation for Expanded Disability Status Scale (EDSS), Multiple Sclerosis Functional Composite (MSFC), and Beck's Depression Scale; and a detailed neuropsychological evaluation masked to the diagnosis. Among the two groups, male/female ratio differed significantly while other demographic and clinical features were not different. In California Verbal Learning Test, both short- and long-term delayed recall and cued recognition were worse in neuro-Behcet's cases. They had impaired semantic clustering and increased false positives. Stroop Test was also more impaired in neuro-Behcet's cases. They needed significantly more trials to complete the first category of the Wisconsin Card Sorting Test and had a poorer total Frontal Behavioral Inventory Score. Our results suggest that neuro-Behcet's patients have a more severe "frontal"-executive dysfunction than MS patients.
多发性硬化症（MS）和神经白塞病（NBD）均可引起主要涉及执行功能的认知功能障碍。我们进行这项研究是为了阐明 MS 和 NBD 可能存在的不同认知/行为特征。连续纳入 20 例脑实质 NBD（13 例男性，7 例女性）和 20 例 MS（5 例男性，15 例女性）患者。两组均进行了详细的神经系统检查；评估扩展残疾状况量表（EDSS）、多发性硬化功能复合量表（MSFC）和贝克抑郁量表；并对诊断进行了详细的神经心理学评估。两组间男性/女性比例差异显著，而其他人口统计学和临床特征无差异。在加利福尼亚词语学习测试中，神经白塞病患者的短时间和长时间延迟回忆以及线索识别均较差。他们存在语义聚类受损和假阳性增加。斯特鲁普测试也在神经白塞病患者中更差。他们需要更多的尝试才能完成威斯康星卡片分类测试的第一类，且总体额叶行为量表评分较差。我们的结果表明，神经白塞病患者的“额叶”执行功能障碍比 MS 患者更严重。
