Fuller G N, Guiloff R J
Department of Neurology, Charing Cross and Westminster Medical School, Westminster Hospital, London, UK.
Cephalalgia. 1990 Oct;10(5):229-33. doi: 10.1046/j.1468-2982.1990.1005229.x.
Propranolol is an established agent in migraine prophylaxis. Uncontrolled studies have suggested an action in the acute attack. We present the first double-blind placebo controlled study of propranolol in 27 unselected patients with common (migraine without aura) and classical (migraine with aura) migraine. There were 23 pairs of headaches in the 14 patients who completed the study. No difference was found, when the data were analysed by headache pair or by patient, in severity duration and subjective assessment of efficacy between those treated in an attack with propranolol 40 mg and placebo.
普萘洛尔是一种公认的偏头痛预防药物。非对照研究提示其对偏头痛急性发作也有作用。我们开展了第一项关于普萘洛尔的双盲安慰剂对照研究，纳入了27例未经挑选的普通型（无先兆偏头痛）和典型偏头痛（有先兆偏头痛）患者。完成研究的14例患者共出现23对头痛发作。当按头痛发作对或按患者对数据进行分析时，发现在偏头痛急性发作时接受40 mg普萘洛尔治疗的患者与接受安慰剂治疗的患者在头痛严重程度、持续时间及主观疗效评估方面均无差异。
