Tabata Y, Ikada Y
Research Center for Medical Polymers and Biomaterials, Kyoto University, Japan.
Crit Rev Ther Drug Carrier Syst. 1990;7(2):121-48.
Macrophages, one of the immunologically competent cells centrally contributing to host defense mechanisms, can be stimulated by a variety of immunomodulatory agents to exert antitumor activity. However, many problems, such as serious side effects attributed to the high-dosage regimens of the drugs, should be addressed for successful tumor immunotherapy using immunomodulatory agents. Thus, it is essential to develop carrier systems that use much lower doses of the drugs. This article reviews the carrier systems of drugs for effective immunopotentiation, especially macrophage activation of antitumor function. Since research in this field has just started, few investigations, including ours, have been reported.
巨噬细胞是在宿主防御机制中发挥核心作用的免疫活性细胞之一，可被多种免疫调节因子刺激以发挥抗肿瘤活性。然而，使用免疫调节因子进行成功的肿瘤免疫治疗时，许多问题，如因高剂量用药方案导致的严重副作用，都需要解决。因此，开发能使用低得多剂量药物的载体系统至关重要。本文综述了用于有效免疫增强，特别是激活巨噬细胞抗肿瘤功能的药物载体系统。由于该领域的研究刚刚起步，包括我们的研究在内，报道的研究很少。
