Yoshimoto A, Nakanishi K, Anzai T, Komine S
Department of Biochemistry, School of Medicine, Kyorin University, Tokyo, Japan.
Cell Biochem Funct. 1990 Oct;8(4):191-8. doi: 10.1002/cbf.290080402.
It has been established that inositol 1,4,5-trisphosphate(IP3) is responsible for the mobilization of calcium(Ca2+) from intracellular locations in a wide variety of tissues, and that this response triggers the stimulation of several hormones and neurotransmitters. However, these phenomena have yet to be examined in the mammary epithelium. Ca2+ uptake from the medium into the endoplasmic reticulum(ER) and Golgi apparatus in vitro in both pregnant and lactating mouse mammary epithelial cells was studied and a strong Ca2+ release from these organelles into the medium with the use of IP3 was shown. The Ca2+ uptake and its release due to IP3 was also usually greater during pregnancy than lactation.
已经确定，肌醇1,4,5 - 三磷酸（IP3）负责在多种组织中从细胞内位点动员钙（Ca2+），并且这种反应会触发多种激素和神经递质的刺激作用。然而，这些现象尚未在乳腺上皮中得到研究。研究了妊娠和泌乳小鼠乳腺上皮细胞在体外从培养基中摄取Ca2+进入内质网（ER）和高尔基体的情况，并显示使用IP3时这些细胞器会向培养基中强烈释放Ca2+。由于IP3导致的Ca2+摄取及其释放通常在妊娠期间也比泌乳期间更大。
