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Xeroderma pigmentosum: clonal chromosomal rearrangements in a pre-cancerous skin lesion.

作者信息

Chessa L, Nuzzo F, Stefanini M, Lagomarsini P, del Porto G

机构信息

Cattedra di Genetica Medica, Università La Sapienza, Roma, Italy.

出版信息

Dis Markers. 1990 May-Jun;8(3):125-36.

PMID:2272148
Abstract

In cells from a papulonodular formation of a patient with the clinical and cellular phenotype of the variant form of xeroderma pigmentosum (XP-V), clonal rearrangements involving different chromosomes were observed. This finding confirms the literature data suggesting that multiple non-specific chromosome anomalies are typical of pre-malignant and malignant skin lesions.

摘要

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