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骨髓生成生物学

The biology of myelopoiesis.

作者信息

Nelson D A

机构信息

Department of Pathology, State University of New York Health Science Center, Syracuse.

出版信息

Clin Lab Med. 1990 Dec;10(4):649-59.

PMID:2272167
Abstract

The myelopoietic system includes the hematopoietic cells derived from a common hematopoietic stem cell that includes erythroid, granulocytic, monocytic, and megakaryocytic lineages. The contributions of molecular genetic techniques to hematopoiesis in the past 5 years have led to quantum leaps in our understanding, but there is room for further research. Current concepts of stem cells and the hematopoietic microenvironment are discussed, as are committed progenitor cells and hematopoietic growth factors, particularly those concerning the neutrophilic, monocytic, and erythroid systems.

摘要

骨髓造血系统包括源自共同造血干细胞的造血细胞,这些造血细胞包括红系、粒系、单核系和巨核系谱系。在过去5年中,分子遗传学技术对造血作用的研究使我们的认识有了巨大飞跃,但仍有进一步研究的空间。本文讨论了干细胞和造血微环境的当前概念,以及定向祖细胞和造血生长因子,特别是与中性粒细胞、单核细胞和红系系统有关的因子。

相似文献

1
The biology of myelopoiesis.骨髓生成生物学
Clin Lab Med. 1990 Dec;10(4):649-59.
2
Effect of stem cell factor on myelopoiesis potential in human Dexter-type culture systems.干细胞因子对人德克斯特型培养体系中髓系造血潜能的影响。
Exp Hematol. 1995 Mar;23(3):202-9.
3
[Proliferation and differentiation in megakaryopoiesis].[巨核细胞生成中的增殖与分化]
Verh Dtsch Ges Pathol. 1990;74:28-35.
4
Marrow-derived heparan sulfate proteoglycan mediates the adhesion of hematopoietic progenitor cells to cytokines.骨髓源性硫酸乙酰肝素蛋白聚糖介导造血祖细胞与细胞因子的黏附。
Exp Hematol. 1995 Oct;23(11):1212-7.
5
Production of colony-stimulating factor(s) for granulocyte-macrophage and multipotential (granulocyte/erythroid/megakaryocyte/macrophage) hematopoietic progenitor cells (CFU-GEMM) by clonal lines of human IL-2-dependent T-lymphocytes.人白细胞介素-2依赖型T淋巴细胞克隆系产生粒细胞-巨噬细胞集落刺激因子及多能(粒细胞/红细胞/巨核细胞/巨噬细胞)造血祖细胞(CFU-GEMM)的情况
Exp Hematol. 1984 Oct;12(9):720-7.
6
Homing efficiency and hematopoietic reconstitution of bone marrow-derived stroma cells expanded by recombinant human macrophage-colony stimulating factor in vitro.重组人巨噬细胞集落刺激因子体外扩增的骨髓源基质细胞的归巢效率及造血重建能力
Exp Hematol. 2004 Dec;32(12):1204-11. doi: 10.1016/j.exphem.2004.08.005.
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Regulation of hematopoiesis in long term marrow cultures: role of humoral factors in the proliferation and differentiation of stem cells and committed progenitors.长期骨髓培养中造血作用的调节:体液因子在干细胞和定向祖细胞增殖及分化中的作用。
Scan Electron Microsc. 1986(Pt 3):1079-86.
8
Organization of haematopoietic stem cells and their relationship to mastocytopoiesis.造血干细胞的组织及其与肥大细胞生成的关系。
Ann Inst Pasteur Immunol. 1986 Sep-Oct;137D(2):187-99.
9
Segregation and characterization of lymphohematopoietic stromal elements.淋巴造血基质成分的分离与鉴定
Kroc Found Ser. 1984;18:211-31.
10
Circadian variations in mouse bone marrow.
Exp Hematol. 1983 Oct;11(9):792-801.

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Differential surface expression of CD18 and CD44 by neutrophils in bone marrow and spleen contributed to the neutrophilia in thalidomide-treated female B6C3F1 mice.沙利度胺处理的雌性B6C3F1小鼠骨髓和脾脏中中性粒细胞CD18和CD44的表面表达差异导致了中性粒细胞增多。
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