Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Clin Transl Oncol. 2012 Jul;14(7):516-9. doi: 10.1007/s12094-012-0834-y.
Cervical cancer (CC) is the second most common cancer worldwide, with a well known origin, infection by high-risk human papilloma virus. Although screening programmes have led to a relevant reduction in the incidence and mortality due to CC in developed countries, it is still an important cause of mortality in young women in undeveloped countries. Clinical stage is the most relevant prognostic factor in CC and the standard of care is still based on it. In early stages, the primary treatment is surgery or radiotherapy, whereas concomitant chemo-radiotherapy is the conventional approach in locally advanced stage. In the setting of recurrent or metastatic CC the treatment is largely palliative, so it is important to develop new therapeutic strategies.
宫颈癌（CC）是全球第二大常见癌症，其明确病因是高危型人乳头瘤病毒（HPV）感染。尽管筛查项目已使发达国家因 CC 导致的发病率和死亡率显著降低，但在发展中国家，CC 仍然是年轻女性死亡的重要原因。临床分期是 CC 最重要的预后因素，目前的治疗标准仍然基于此。在早期阶段，主要治疗方法是手术或放疗，而局部晚期则采用同期放化疗。对于复发性或转移性 CC，治疗主要是姑息性的，因此开发新的治疗策略非常重要。
