Luoma P V, Myllylä V V, Sotaniemi E A, Hokkanen T E
Acta Neurol Scand. 1979 Jul;60(1):56-63. doi: 10.1111/j.1600-0404.1979.tb02951.x.
Due to the metabolic changes induced, e.g. in the liver by anti-epileptic drugs, the significance of high serum triglyceride and cholesterol in epileptics was studied and the plasma HDL cholesterol level was compared in 190 epileptic patients with elevated or normal triglyceride and cholesterol, with the corresponding values in 43 healthy subjects. One-third of the epileptic patients showed elevated plasma HDL cholesterol levels. Female epileptics had higher plasma HDL cholesterol than the normolipidemic healthy subjects. Epileptics with elevated triglyceride or a combination of elevated triglyceride and cholesterol had a lower plasma HDL cholesterol level than normolipidemic patients with epilepsy. HDL cholesterol level in epileptics with high serum cholesterol did not diverge from the level in epileptics with normal serum triglyceride and cholesterol. The results show significant differences of plasma HDL cholesterol between epileptic patients and normolipidemic healthy controls on one hand, and between epileptics with altered and epileptics with normal serum lipid levels on the other. The findings suggest that the increase of plasma HDL cholesterol level in epileptics undergoing anticonvulsant treatment is influenced by endogenous triglyceride metabolism.
由于抗癫痫药物等诱导的代谢变化，研究了癫痫患者血清甘油三酯和胆固醇升高的意义，并比较了190例甘油三酯和胆固醇升高或正常的癫痫患者与43名健康受试者的血浆高密度脂蛋白胆固醇水平。三分之一的癫痫患者血浆高密度脂蛋白胆固醇水平升高。女性癫痫患者的血浆高密度脂蛋白胆固醇高于血脂正常的健康受试者。甘油三酯升高或甘油三酯和胆固醇均升高的癫痫患者的血浆高密度脂蛋白胆固醇水平低于血脂正常的癫痫患者。血清胆固醇高的癫痫患者的高密度脂蛋白胆固醇水平与血清甘油三酯和胆固醇正常的癫痫患者的水平没有差异。结果表明，一方面癫痫患者与血脂正常的健康对照之间血浆高密度脂蛋白胆固醇存在显著差异，另一方面血清脂质水平改变的癫痫患者与血清脂质水平正常的癫痫患者之间也存在显著差异。研究结果表明，接受抗惊厥治疗的癫痫患者血浆高密度脂蛋白胆固醇水平的升高受内源性甘油三酯代谢的影响。
