Thompson G A, Smithers J, Boxenbaum H
Drug Metabolism Department, Merrell Dow Research Institute, Cincinnati, Ohio 45215-6300.
Drug Metab Rev. 1990;22(2-3):269-89. doi: 10.3109/03602539009041086.
Based on survivalship data from Tryon and Snyder, wild chipmunks (Tamias striatus), captured, exposed to single doses of either 200 or 400 rad ionizing radiation, and subsequently returned to their natural habitat, exhibited a biphasic response in age-specific mortality rate (omega x). On the one hand, a residuum of unrepaired toxicity (injury) appeared to persist and manifest itself throughout life (enhancement of omega x values). A second response, termed longevity hormesis (of unknown mechanism), was also observed. This phenomenon initially reduced omega x values but was reversible. A relatively simple mathematical model characterizing differences in mortality experience between control and irradiated populations was formulated and tested. Although there were some shortcomings, the model characterized the data reasonably well.
根据特赖恩和斯奈德的生存数据，野生花栗鼠（美洲花鼠）被捕获后接受200或400拉德单剂量的电离辐射，随后放回其自然栖息地，其年龄特异性死亡率（ωx）呈现双相反应。一方面，未修复的毒性（损伤）残余似乎会持续存在，并在整个生命过程中表现出来（ωx值升高）。还观察到了第二种反应，称为长寿兴奋效应（机制不明）。这种现象最初会降低ωx值，但具有可逆性。我们制定并测试了一个相对简单的数学模型，该模型描述了对照种群和受辐照种群在死亡经历上的差异。尽管存在一些缺点，但该模型对数据的拟合效果还算不错。
