Marrosu F, Mereu G, Carcangiu G, Passino N, Giagheddu M
Department of Experimental Biology, University of Cagliari, Italy.
Epilepsy Res. 1990 Aug;6(3):205-10. doi: 10.1016/0920-1211(90)90074-6.
Diphenylhydantoin (DPH) has recently been reported to produce dopaminergic (DA) supersensitivity in animals. These results have suggested that the dyskinesias observed in humans after DPH, although rare, might be regarded as a neuroleptic-like effect. Indeed dyskinesias would be induced by an inactivation of post-synaptic DAergic receptors, operated by DPH, and therefore reminiscent of that observable in neuroleptic treatment. In order to investigate this matter, we studied the effects of i.v. DPH on the extracellular single unit activity of DAergic cells located in mid-brain areas of rats. DPH was injected alone or in combination with DA antagonists such as L-sulpiride (L-SULP) and haloperidol (HAL), or the DAergic agonist apomorphine (APO). Our results show that DPH did not affect spontaneous DAergic firing rate and also failed to modify the known action of the DA agonists and antagonists which were tested on these neurons.
最近有报道称，苯妥英（DPH）可使动物产生多巴胺能（DA）超敏反应。这些结果表明，人类服用DPH后出现的运动障碍虽然罕见，但可能被视为一种类抗精神病药物效应。事实上，运动障碍可能是由DPH作用导致的突触后多巴胺能受体失活引起的，因此与抗精神病药物治疗中可观察到的情况相似。为了研究这个问题，我们研究了静脉注射DPH对大鼠中脑区域多巴胺能细胞的细胞外单单位活动的影响。单独注射DPH，或与多巴胺拮抗剂如L-舒必利（L-SULP）和氟哌啶醇（HAL），或多巴胺能激动剂阿扑吗啡（APO）联合注射。我们的结果表明，DPH不影响多巴胺能神经元的自发放电率，也未能改变对这些神经元进行测试的多巴胺激动剂和拮抗剂的已知作用。
