Saano V, Paronen P, Peura P
Department of Pharmacology, University of Kuopio, Finland.
Int J Clin Pharmacol Ther Toxicol. 1990 Nov;28(11):471-4.
Doxycycline (DC) is used either as solid form hydrochloride capsules, or as monohydrate tablets, which may be taken either as solid form tablets or dissolved in water. In this single dose (150 mg), crossover study on 15 healthy volunteers, the pharmacokinetic properties of DC from hydrochloride tablets taken either in dissolved or in solid form were compared with those observed after taking dissolved DC as a monohydrate tablet. The results of this study show that DC is absorbed rapidly (tmax 3.3-3.8 h) and with equal bioavailability (AUC values 52.9-58.5 mg/l x h) from both hydrochloride and monohydrate tablets. It can be concluded that taking the DC hydrochloride tablets in dissolved form does not affect the pharmacokinetics of DC, moreover the bioavailability of DC is comparable to that achieved after taking DC monohydrate tablets in dissolved form.
强力霉素（DC）有盐酸盐胶囊这种固体剂型，也有一水合物片剂，既可以服用固体片剂，也可以溶于水服用。在这项针对15名健康志愿者的单剂量（150毫克）交叉研究中，比较了服用溶解状态或固体状态的盐酸盐片剂后DC的药代动力学特性，与服用溶解状态的一水合物片剂后观察到的药代动力学特性。该研究结果表明，盐酸盐片剂和一水合物片剂中的DC吸收迅速（达峰时间为3.3 - 3.8小时），且生物利用度相同（曲线下面积值为52.9 - 58.5毫克/升×小时）。可以得出结论，溶解状态服用盐酸强力霉素片不会影响DC的药代动力学，而且DC的生物利用度与溶解状态服用一水合物片剂后的生物利用度相当。
