严重小于胎龄儿与认知功能：追赶生长现象可能存在。

Severe small size for gestational age and cognitive function: catch-up phenomenon possible.

机构信息

Department of Psychology, Old Dominion University, Norfolk, VA, USA.

出版信息

Am J Obstet Gynecol. 2012 Aug;207(2):119.e1-5. doi: 10.1016/j.ajog.2012.05.026. Epub 2012 Jun 11.

DOI:10.1016/j.ajog.2012.05.026

PMID:22728029

Abstract

OBJECTIVE

We sought to compare cognitive functioning in children born with birthweight <3% vs ≥3% for gestational age (GA) between 9 months and kindergarten.

STUDY DESIGN

Nonanomalous singletons from the Early Childhood Longitudinal Study-Birth Cohort were included. Associations between weight for GA and cognitive functioning were examined using a series of confounder-adjusted general linear models.

RESULTS

Of 3633 cohorts, 585 (16%) were <3% for GA. At 9 months, cognitive performance of newborns <3% was about 12 percentile points lower than their normal counterparts (P < .001). By 2 years, however, no significant cognitive differences between these groups were observed (P = .668). Academic performance at preschool age (around 3.5 years) was not different for reading (P = .245) or math (P = .880), nor different at kindergarten age.

CONCLUSION

Newborns <3% for GA exhibit catch-up cognitive functioning by 2 years, with relatively no decrements in academic functioning observed by kindergarten.

摘要

目的

我们旨在比较胎龄（GA）小于 3%和≥3%的出生体重儿在 9 个月至幼儿园期间的认知功能。

研究设计

纳入了来自儿童纵向研究出生队列的非异常单胎儿。使用一系列混杂因素调整的线性模型来检查体重与认知功能之间的关联。

结果

在 3633 个队列中，有 585 个（16%）小于 3%的 GA。在 9 个月时，<3%GA 的新生儿的认知表现比正常儿低约 12 个百分点（P<0.001）。然而，到 2 岁时，这些组之间没有观察到显著的认知差异（P=0.668）。在学龄前（约 3.5 岁），阅读（P=0.245）或数学（P=0.880）的学业成绩两组之间没有差异，在幼儿园年龄也没有差异。